Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 2390 |
| PDBID: | 6K67 |
| Chains: | C_D |
| Organism: | Homo sapiens |
| Method: | XRD |
| Resolution (Å): | 1.95 |
| Reference: | 10.1073/pnas.1910080116 |
| Antibody | |
| Antibody: | Anti-huntingtin VL-intrabody |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Protein A #9011 |
| Antigen mutation: | No |
| Durg Target: | P0DP25; P0DP24; P0DP23; |
Sequence information
Antibody
Chain: C
Mutation: NULL
| >6K67_C|Chain A, C|3LRH introbody|Homo sapiens (9606) MGSSHHHHHHSSGLVPRGSHMGSQPVLTQSPSVSAAPRQRVTISVSGSNSNIGSNTVNWIQQLPGRAPELLMYDDDLLAPGVSDRFSGSRSGTSASLTISGLQSEDEADYYAATWDDSLNGWVFGGGTKVTVLSA |
Antigen
Chain: D
Mutation: NULL
| >6K67_D|Chain B, D|Engineered calmodulin|Homo sapiens (9606) MGSSHHHHHHSSGLVPRGSHMEKLMKAFESLQIFQFKEAFSLFDKDGDGTITTKELGTVMRSLGQNPTEAELQDMINEVDADGNGTIDFPEFLTMMARKMKDTD |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| C: ASN35 ILE37 GLN39 ALA44 PRO45 GLU46 LEU47 TYR50 ASP51 LEU54 ALA56 PRO57 TYR88 ALA90 TRP92 TRP99 PHE101 D: HIS3 LYS6 LEU7 LYS9 ALA10 PHE11 GLU12 SER13 LEU14 ILE16 PHE17 GLN18 LYS20 GLU21 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
