Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 2388 |
| PDBID: | 6K64 |
| Chains: | B_H |
| Organism: | Homo sapiens, Staphylococcus aureus |
| Method: | XRD |
| Resolution (Å): | 1.93 |
| Reference: | 10.1073/pnas.1910080116 |
| Antibody | |
| Antibody: | Anti-huntingtin VL-intrabody |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Protein A #8188 |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Chain: B
Mutation: NULL
| >6K64_B|Chain A, B|3LRH intrabody|Homo sapiens (9606) MGSSHHHHHHSSGLVPRGSHMGSQPVLTQSPSVSAAPRQRVTISVSGSNSNIGSNTVNWIQQLPGRAPELLMYDDDLLAPGVSDRFSGSRSGTSASLTISGLQSEDEADYYAATWDDSLNGWVFGGGTKVTVLSA |
Antigen
Chain: H
Mutation: NULL
| >6K64_H|Chain C, D[auth H]|Protein A|Staphylococcus aureus subsp. aureus (1280) MGSSHHHHHHSSGLVPRGSHMFNKDQQSAFYEILNMPNLNEAQRNGFIQSLKDDPSQSTNVLGEAKKLNKAQASLKSFQ |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| Chain residues position delta_SASA
: residuesposition B: ASN38 ILE40 GLN42 PRO48 GLU49 LEU50 TYR53 ASP54 LEU57 ALA59 PRO60 TYR91 ALA93 TRP102 PHE104 H: ASN21 ALA23 GLN24 GLY27 PHE28 GLU45 LYS48 LEU49 LYS51 ALA52 GLN53 ALA54 SER55 LEU56 SER58 PHE59 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 6 Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 6 Å from any atom.
Interacting residues (Atom distance based)
