Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 2387 |
| PDBID: | 6K64 |
| Chains: | A_C |
| Organism: | Homo sapiens, Staphylococcus aureus |
| Method: | XRD |
| Resolution (Å): | 1.93 |
| Reference: | 10.1073/pnas.1910080116 |
| Antibody | |
| Antibody: | Anti-huntingtin VL-intrabody |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Protein A #8188 |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Chain: A
Mutation: NULL
| >6K64_A|Chain A, B|3LRH intrabody|Homo sapiens (9606) MGSSHHHHHHSSGLVPRGSHMGSQPVLTQSPSVSAAPRQRVTISVSGSNSNIGSNTVNWIQQLPGRAPELLMYDDDLLAPGVSDRFSGSRSGTSASLTISGLQSEDEADYYAATWDDSLNGWVFGGGTKVTVLSA |
Antigen
Chain: C
Mutation: NULL
| >6K64_C|Chain C, D[auth H]|Protein A|Staphylococcus aureus subsp. aureus (1280) MGSSHHHHHHSSGLVPRGSHMFNKDQQSAFYEILNMPNLNEAQRNGFIQSLKDDPSQSTNVLGEAKKLNKAQASLKSFQ |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| A: ASN38 ILE40 GLN42 PRO48 GLU49 LEU50 TYR53 ASP54 LEU57 ALA59 PRO60 TYR91 ALA93 TRP102 PHE104 C: ASN2821 ALA2823 GLN2824 GLY2827 PHE2828 GLU2845 LYS2848 LEU2849 LYS2851 ALA2852 GLN2853 ALA2854 SER2855 LEU2856 SER2858 PHE2859 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
