Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 2374 |
| PDBID: | 6JMQ |
| Chains: | DC_B |
| Organism: | Homo sapiens, Mus musculus |
| Method: | EM |
| Resolution (Å): | 3.31 |
| Reference: | 10.1038/s41594-019-0237-7 |
| Antibody | |
| Antibody: | MEM-108 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | 4F2 cell-surface antigen heavy chain |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: D
Mutation: NULL
| >6JMQ_D|Chain D|Antibody|Mus musculus (10090) DIVMSQSPSSLVVSVGEKVTMSCXXXXXXXXXXXXXXXXXWYQQKPGQSPKLLIYXXXXXXXGVPDRFTGSGSGTDFTLTISSVKAEDLAVYYCXXXXXXXXXFGGGTKLEIKRADAAPTVSIFPPSSEQLTSGGASVVCFLNNFYPKDINVKWKIDGSERQNGVLNSWTDQDSKDSTYSMSSTLTLTKDEYERHNSYTCEATHKTSTSPIVKSFNRNE |
Light Chain: C
Mutation: NULL
| >6JMQ_C|Chain C|Antibody|Mus musculus (10090) QVQLKESGPGLVAPSQSLSITCTVSGFPLTXXXXXWVRQPPGKGLEWLGXXXXXXXXXXXXXXXXRLSISKDNSKSQVFLKMNSLQTDDTARYYCARXXXXXXXXXXWGQGTSVTVSSAKTTPPSVYPLAPGSXXXXXSMVTLGCLVKGYFPEPVTVTWNSGSLSSGVHTFPAVLQSDLYTLSSSVTVPSSTWPSETVTCNVAHPASSTKVDKKIVPRD |
Antigen
Chain: B
Mutation: NULL
| >6JMQ_B|Chain B|4F2 cell-surface antigen heavy chain|Homo sapiens (9606) GSELQPPEASIAVVSIPRQLPGSHSEAGVQGLSAGDDSELGSHCVAQTGLELLASGDPLPSASQNAEMIETGSDCVTQAGLQLLASSDPPALASKNAEVTGTMSQDTEVDMKEVELNELEPEKQPMNAASGAAMSLAGAEKNGLVKIKVAEDEAEAAAAAKFTGLSKEELLKVAGSPGWVRTRWALLLLFWLGWLGMLAGAVVIIVRAPRCRELPAQKWWHTGALYRIGDLQAFQGHGAGNLAGLKGRLDYLSSLKVKGLVLGPIHKNQKDDVAQTDLLQIDPNFGSKEDFDSLLQSAKKKSIRVILDLTPNYRGENSWFSTQVDTVATKVKDALEFWLQAGVDGFQVRDIENLKDASSFLAEWQNITKGFSEDRLLIAGTNSSDLQQILSLLESNKDLLLTSSYLSDSGSTGEHTKSLVTQYLNATGNRWCSWSLSQARLLTSFLPAQLLRLYQLMLFTLPGTPVFSYGDEIGLDAAALPGQPMEAPVMLWDESSFPDIPGAVSANMTVKGQSEDPGSLLSLFRRLSDQRSKERSLLHGDFHAFSAGPGLFSYIRHWDQNERFLVVLNFGDVGLSAGLQASDLPASASLPAKADLLLSTQPGREEGSPLELERLKLEPHEGLLLRFPYAA |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| C: THR30 UNK31 UNK50 UNK51 UNK52 UNK56 UNK57 UNK58 UNK100 UNK101 UNK102 UNK103 D: UNK31 UNK33 UNK34 UNK97 UNK98 UNK99 UNK100 B: THR411 GLU413 GLN448 ALA546 GLY547 PRO548 GLY549 GLY570 ASP571 VAL572 GLY573 LEU574 SER575 GLN600 PRO601 LYS615 PRO618 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
