Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 2370 |
| PDBID: | 6JEP |
| Chains: | HL_E |
| Organism: | Homo sapiens, Zika virus |
| Method: | XRD |
| Resolution (Å): | 2.32 |
| Reference: | 10.1016/j.celrep.2019.02.062 |
| Antibody | |
| Antibody: | ZK2B10 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Zika virus Genome polyprotein |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: H
Mutation: NULL
| >6JEP_H|Chain A[auth H], D[auth K]|heavy chain of Fab ZK2B10|Homo sapiens (9606) EVQLVQSGAEVKKPGASVKVSCKASGYTFTSGHTFPSYDINWVRQATGQGLEWMGWMNPNRGNTGYAQKFQGRVTMTRNTSINTAYMELSSLRSEDTAVYYCARVRSGTNYGSYYYYYYGMDVWGQGTTVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPK |
Light Chain: L
Mutation: NULL
| >6JEP_L|Chain B[auth I], E[auth L]|light chain of Fab ZK2B10|Homo sapiens (9606) SYELTQPPSASGTPGQRVTISCSGSSSNIGNNYVHWYQQLPGSAPKLLIYRNNQRPSGVPDRFSGSKSGTSGSLAISGLRSEDEADYYCASWDDSLSGHWVFGGGTKVTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPT |
Antigen
Chain: E
Mutation: NULL
| >6JEP_E|Chain C[auth E], F|Genome polyprotein|Zika virus (64320) VSYSLCTAAFTFTKIPAETLHGTVTVEVQYAGTDGPCKVPAQMAVDMQTLTPVGRLITANPVITESTENSKMMLELDPPFGDSYIVIGVGEKKITHHWHRS |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| H: THR109 ASN110 TYR111 GLY112 TYR114 TYR116 TYR118 TYR119 L: SER26 GLY30 ASN31 ASN32 TYR33 ARG51 LYS67 ASP94 SER95 LEU96 E: THR309 ALA310 ALA311 PHE312 THR313 GLN331 ALA333 GLY334 THR335 ASP336 THR369 GLU370 ASN371 GLU393 LYS394 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
