Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 2364 |
| PDBID: | 6J6Y |
| Chains: | EF_D |
| Organism: | Homo sapiens, synthetic construct |
| Method: | XRD |
| Resolution (Å): | 2.15 |
| Reference: | 10.1158/1535-7163.MCT-18-0048 |
| Antibody | |
| Antibody: | FGFR4 D2 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Fibroblast growth factor receptor 4 |
| Antigen mutation: | No |
| Durg Target: | P22455 |
Sequence information
Antibody
Heavy Chain: E
Mutation: NULL
| >6J6Y_E|Chain B, E|Fab Heavy chain|synthetic construct (32630) KLAATMKHLWFFLLLVAAPRWVLSEVQLLESGGGLVQPGGSLRLSCAASGFTFSDYYMSWIRQAPGKGLEWVSTISGSGGSTYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCARLTAYGHVDSWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTH |
Light Chain: F
Mutation: NULL
| >6J6Y_F|Chain C, F|Fab light chain|synthetic construct (32630) KLAATMVLQTQVFISLLLWISGAYGQSVLTQPPSASGTPGQRVTISCSGSSSNIGTNTVNWYQQLPGTAPKLLIYRNYQRPSGVPDRFSGSKSGTSASLAISGLRSEDEADYYCAAWDDSLSGPHVVFGGGTKLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS |
Antigen
Chain: D
Mutation: NULL
| >6J6Y_D|Chain A, D|Fibroblast growth factor receptor 4|Homo sapiens (9606) SYPQQAPYWTHPQRMEKKLHAVPAGNTVKFRCPAAGNPTPTIRWLKDGQAFHGENRIGGIRLRHQHWSLVMESVVPSDRGTYTCLVENAVGSIRYNYLLDVLER |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| E: SER30 ASP31 TYR33 SER52 GLY53 SER54 GLY56 SER57 TYR59 LEU99 THR100 ALA101 TYR102 GLY103 F: SER24 SER25 GLY28 THR29 ASN30 THR31 ARG49 ASN50 TYR51 TRP90 ASP92 SER93 LEU94 GLY96 PRO97 D: TRP156 PRO159 GLN160 MET162 GLU163 LYS164 LYS165 LEU166 HIS167 ALA168 ARG226 GLY227 THR228 ILE240 ARG241 TYR242 ASN243 LEU245 LEU246 ASP247 VAL248 LEU249 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
