Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 2360 |
| PDBID: | 6J5D |
| Chains: | HL_A |
| Organism: | Louping ill virus, Mus musculus |
| Method: | XRD |
| Resolution (Å): | 1.80 |
| Reference: | 10.1128/JVI.02132-18 |
| Antibody | |
| Antibody: | 4.2 Fv |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | louping ill virus envelope protein Domain III |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: H
Mutation: NULL
| >6J5D_H|Chain B[auth H]|antibody heavy chain|Mus musculus (10090) QVQLQQSGPELVKPGASVKMSCKASGYTFTDYVIGWVKQRTGQGLEWIGEIYPGSGTTYYNEKFKDKATLTADKSSNTAYMQLSSLTSEDSAVYFCARGEDGYYIALDYWGQGTTVTVSS |
Light Chain: L
Mutation: NULL
| >6J5D_L|Chain C[auth L]|antibody light chain|Mus musculus (10090) DIELTQSPASLSASVGETVTITCRASGNIHNYLAWYQQKQGKSPQLLVYKAQTLADGVPSRFSGSGSGTQYSLKINSLQPEDFGSYYCQHFWSTPPWTFGGGTKLEIKR |
Antigen
Chain: A
Mutation: NULL
| >6J5D_A|Chain A|Envelope|Louping ill virus (11086) GLTYTMCDKSKFAWKRTPTDSGHDTVVMEVTFSGSKPCRIPVRAVAHGSPDVNVAMLITPNPTIENDGGGFIEMQLPPGDNIIYVGELSHQWFQTGSSIGR |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| H: TYR52 SER55 THR57 TYR59 ASP101 GLY102 TYR103 TYR104 ILE105 L: HIS30 TYR32 LYS50 PHE91 TRP92 SER93 THR94 PRO95 TRP97 A: MET306 ASP308 LYS309 SER310 LYS311 PHE312 ALA313 PHE332 SER333 GLY334 SER335 LYS336 PRO337 ASN366 GLU387 LEU388 SER389 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
