Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 2347 |
| PDBID: | 6IW0 |
| Chains: | HL_A |
| Organism: | Yellow fever virus 17D, Homo sapiens |
| Method: | XRD |
| Resolution (Å): | 3.60 |
| Reference: | 10.1016/j.celrep.2018.12.065 |
| Antibody | |
| Antibody: | 5A Fv |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Yellow fever virus (YFV) Envelope protein E |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: H
Mutation: NULL
| >6IW0_H|Chain B[auth H]|Heavy chain of monoclonal antibody 5A|Homo sapiens (9606) MEVQLVESGPRLVKPSETLSLTCTVSGGSTYNHHWSWIRQPPGRGLEWIGYISYSGKSNYNPSLKSRVTISLEPSTTQFSLKLNSLTAADTAVYYCAREYRDDTNYYYYSLDVWGPGTMVTVSSGGGGSGGGGSGGGGSGGGGSQ |
Light Chain: L
Mutation: NULL
| >6IW0_L|Chain C[auth L]|Light chain of monoclonal antibody 5A|Homo sapiens (9606) IVMTQSPSTLSASVGDRVTITCRASQSIGSWLAWYQQKPGKAPKLLIYKASSLESGVPSRFSGSGSGTEFTLTISSLQPEDFATYYCQQYNNYSYTFGPGTKLEIKR |
Antigen
Chain: A
Mutation: NULL
| >6IW0_A|Chain A|Envelope protein E|Yellow fever virus (strain 17D vaccine) (11090) AHCIGITDRDFIEGVHGGTWVSATLEQDKCVTVMAPDKPSLDISLETVAIDRPAEVRKVCYNAVLTHVKINDKCPSTGEAHLAEENEGDNACKRTYSDRGWGNGCGLFGKGSIVACAKFTCAKSMSLFEVDQTKIQYVIRAQLHVGAKQENWNTDIKTLKFDALSGSQEVEFIGYGKATLECQVQTAVDFGNSYIAEMETESWIVDRQWAQDLTLPWQSGSGGVWREMHHLVEFEPPHAATIRVLALGNQEGSLKTALTGAMRVTKDTNDNNLYKLHGGHVSCRVKLSALTLKGTSYKICTDKMFFVKNPTDTGHGTVVMQVKVSKGAPCRIPVIVADDLTAAINKGILVTVNPIASTNDDEVLIEVNPPFGDSYIIVGRGDSRLTYQWHKEGSS |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| H: GLU2 VAL3 GLY27 GLY28 SER29 THR30 TYR31 ASN32 HIS33 TYR54 PRO74 SER75 ARG98 TYR100 ARG101 ASP102 ASP103 THR104 ASN105 TYR106 TYR107 ASP112 L: TYR49 LEU54 GLU55 SER56 A: LEU65 THR66 HIS67 VAL68 LYS69 ILE70 ASN71 ASP72 LYS73 CYS74 HIS81 LEU82 ALA83 GLU84 GLU87 ARG99 TRP101 GLY102 ASN103 GLY104 CYS105 GLY106 HIS238 ALA239 ALA240 THR241 ILE242 ARG243 VAL244 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
