Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 2345 |
| PDBID: | 6IUV |
| Chains: | CD_B |
| Organism: | Influenza A virus (A/Hong Kong/482/97(H5N1)), Homo sapiens |
| Method: | XRD |
| Resolution (Å): | 2.33 |
| Reference: | 10.1074/jbc.RA118.007008 |
| Antibody | |
| Antibody: | 3C11 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Influenza A virus H5N1 hemagglutinin |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: C
Mutation: NULL
| >6IUV_C|Chain C, F[auth H]|3C11 Heavy Chain|Homo sapiens (9606) QVQLVQSGAEVKETGESLNISCKVSGNNFPSYYISWVRQMPGNGLEWMGRIDPSDSDTNYRPSFQGHVTISADKSTSTAYLQWRSLKASDTAMYYCARRATYYYGSGSYFDAFDIWGQGTMVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSC |
Light Chain: D
Mutation: NULL
| >6IUV_D|Chain B[auth D], E[auth L]|3C11 Light Chain|Homo sapiens (9606) EIVMTQSPLTLPVTPGAPASISCRSSQSLLHSDGYNYLDWYLQKPGQSPQLLIYLGSHRASGVPDRFSGSGSGTDFTLKISRVEAEDVGVYYCMQALQTPDFGQGTRLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC |
Antigen
Chain: B
Mutation: NULL
| >6IUV_B|Chain A, D[auth B]|Hemagglutinin|Influenza A virus (A/Hong Kong/482/97(H5N1)) (155218) NGVKPLILRDCSVAGWLLGNPMCDEFINVPEWSYIVEKASPANDLCYPGNFNDYEELKHLLSRINHFEKIQIIPKSSWSNHDASSGVSSACPYLGRSSFFRNVVWLIKKNSAYPTIKRSYNNTNQEDLLVLWGIHHPNDAAEQTKLYQNPTTYISVGTSTLNQRLVPEIATRPKVNGQSGRMEFFWTILKPNDAINFESNGNFIAPEYAYKIVKKGDSTIMKSE |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| D: HIS31 SER32 ASP33 C: ASN27 PHE29 PRO30 SER31 TYR32 TYR33 ASP52 ASP55 ASP57 THR101 TYR102 TYR103 TYR104 GLY105 SER106 GLY107 B: ILE114 GLN115 ILE116 ILE117 PRO118 SER120 SER121 SER123 ASN124 LYS161 ARG162 SER163 TYR164 ASN165 THR167 ASN168 GLY201 THR202 SER203 ASP237 ALA238 ASN240 GLU242 LYS255 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
