Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 2343 |
| PDBID: | 6IUT |
| Chains: | HL_A |
| Organism: | Homo sapiens, Influenza A virus (A/Anhui/1/2005(H5N1)) |
| Method: | XRD |
| Resolution (Å): | 2.30 |
| Reference: | 10.1074/jbc.RA118.007008 |
| Antibody | |
| Antibody: | AVFluIgG01 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Influenza A virus H5N1 hemagglutinin |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: H
Mutation: NULL
| >6IUT_H|Chain A[auth H]|AVFluIgG01 Heavy Chain|Homo sapiens (9606) VQLQESGPGLVKPSETLSLTCTVSGGSINSYYWSWIRQPPGKGLEWIGYLFDSGSTKYNPSLTSRVTISVDTSKNQFSLKLSSVTAADTAVYYCARGFWGLDGFDIWGQGTTVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKS |
Light Chain: L
Mutation: NULL
| >6IUT_L|Chain B[auth L]|AVFluIgG01 Light Chain|Homo sapiens (9606) AVLTQPASVSGSPGQSITISCTGTSSDVGDYNYVSWYQQHPGKAPTLMIYDVNKRPSGDSNRFSGSKSGNTASLTISGLQAEDEADYYCSSYTSSNTWVFGGGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC |
Antigen
Chain: A
Mutation: NULL
| >6IUT_A|Chain C[auth A]|Hemagglutinin|Influenza A virus (A/Anhui/1/2005(H5N1)) (370810) DGVKPLILRDCSVAGWLLGNPMCDEFINVPEWSYIVEKANPANDLCYPGNFNDYEELKHLLSRINHFEKIQIIPKSSWSDHEASSGVSSACPYQGTPSFFRNVVWLIKKNNTYPTIKRSYNNTNQEDLLILWGIHHSNDAAEQTKLYQNPTTYISVGTSTLNQRLVPKIATRSKVNGQSGRMDFFWTILKPNDAINFESNGNFIAPEYAYKIVKKGDSAIVKSEHHHHHH |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| H: ASN29 SER30 TYR31 TYR49 PHE51 ASP52 SER53 SER55 THR56 LYS57 THR72 PHE98 TRP99 GLY100 LEU101 ASP102 L: ASP29 TYR30 TYR32 TYR49 LYS53 TYR91 SER93 ASN95 A: GLN115 ILE116 ILE117 PRO118 SER120 SER121 TRP122 SER123 ASP124 HIS125 PRO158 THR159 ILE160 LYS161 ARG162 SER163 TYR164 ASN165 THR167 ASN168 ASN240 PHE241 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
