Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 2342 |
| PDBID: | 6IR2 |
| Chains: | B_A |
| Organism: | Anaplasma marginale, Camelus bactrianus |
| Method: | XRD |
| Resolution (Å): | 1.39 |
| Reference: | 10.1002/pro.4194 |
| Antibody | |
| Antibody: | LaM2 Nanobody |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | MCherry fluorescent protein |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Chain: B
Mutation: NULL
| >6IR2_B|Chain B|mCherry's nanobody LaM2|Camelus bactrianus (9837) SAQVQLVESGGGLVQAGGSLRLSCATSGFTFSDYAMGWFRQAPGKEREFVAAISWSGHVTDYADSVKGRFTISRDNVKNTVYLQMNSLKPEDTAVYSCAAAKSGTWWYQRSENDFGSWGQGTQVTVS |
Antigen
Chain: A
Mutation: NULL
| >6IR2_A|Chain A|MCherry fluorescent protein|Anaplasma marginale (770) GMVSKGEEDNMAIIKEFMRFKVHMEGSVNGHEFEIEGEGEGRPYEGTQTAKLKVTKGGPLPFAWDILSPQFMYGSKAYVKHPADIPDYLKLSFPEGFKWERVMNFEDGGVVTVTQDSSLQDGEFIYKVKLRGTNFPSDGPVMQKKTMGWEASSERMYPEDGALKGEIKQRLKLKDGGHYDAEVKTTYKAKKPVQLPGAYNVNIKLDITSHNEDYTIVEQYERAEGRH |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| B: SER44 ASP45 SER66 TRP67 SER68 HIS70 VAL71 ASP87 ASN88 VAL89 GLY116 THR117 TRP118 TRP119 TYR120 GLN121 A: GLU19 LYS92 TRP93 GLU94 ARG95 VAL96 THR106 VAL107 THR108 ASP110 LYS123 LEU124 ARG125 ASP154 LYS158 LYS178 THR179 THR180 LYS182 LYS184 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
