Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 2340 |
| PDBID: | 6ION |
| Chains: | HL_A |
| Organism: | Mus musculus, Homo sapiens |
| Method: | XRD |
| Resolution (Å): | 2.75 |
| Reference: | 10.7150/ijbs.39919 |
| Antibody | |
| Antibody: | 11H10 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Ly6/PLAUR domain-containing protein 3 (C4.4A) |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: H
Mutation: NULL
| >6ION_H|Chain B[auth H]|anti-C4.4A antibody 11H10, heavy chain|Mus musculus (10090) QVTLKESGPGILQPSQTLSLTCSFSGFSLNSFGTGVGWIRQPSGKGLEWLAHIWWNDYKYYNAALESRLTISKDTSNNQVFLKIASVDTADTATYYCARLRLRYFDYWGQGTTLTVSSAKTTPPSVYPLAPGSAAQTNSMVTLGCLVKGYFPEPVTVTWNSGSLSSGVHTFPAVLQSDLYTLSSSVTVPSSTWPSETVTCNVAHPASSTKVDKKIVPRDC |
Light Chain: L
Mutation: NULL
| >6ION_L|Chain A[auth L]|anti-C4.4A antibody 11H10, light chain|Mus musculus (10090) DILMTQSPAILSVSPGEGVSFSCWANQNIGTSIHWYQQRTNGSPRLLIKYASESISGIPSRFSGSGSGTDFTLSINSVESEDIADYYCQQSNSWPIFTFGSGTKLEIKRADAAPTVSIFPPSSEQLTSGGASVVCFLNNFYPKDINVKWKIDGSERQNGVLNSWTDQDSKDSTYSMSSTLTLTKDEYERHNSYTCEATHKTSTSPIVKSFNRNEC |
Antigen
Chain: A
Mutation: NULL
| >6ION_A|Chain C[auth A]|Ly6/PLAUR domain-containing protein 3|Homo sapiens (9606) LECYSCVQKADDGCSPNKMKTVKCAPGVDVCTEAVGAVETIHGQFSLAVRGCGSGLPGKNDRGLDLHGLLAFIQLQQCAQDRCNAKLNLTSRALDPAGNESAYPPNGVECYSCVGLSREACQGTSPPVVSCYNASDHVYKGCFDGNVTLTAANVTVSLPVRGCVQDEFCTRDGVTGPGFTLSGSCCQGSRCNSDLRNKTYF |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| L: LYS49 TYR50 TRP94 PRO95 H: PHE32 GLY33 TRP54 TRP55 ASN56 TYR58 LYS59 TYR60 GLU66 ARG101 LEU102 ARG103 TYR104 A: VAL35 ALA37 GLU39 THR40 ILE41 GLN44 ASP61 ARG62 GLY63 LEU64 ASP65 HIS67 GLY68 LEU70 PHE72 ILE73 GLN74 TYR132 ALA134 SER135 ASP136 HIS137 TYR139 GLN165 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
