Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 2322 |
| PDBID: | 6II9 |
| Chains: | PQ_E |
| Organism: | Influenza A virus (A/Anhui/DEWH72-02/2013(H7N9)), Influenza A virus (A/Anhui/1-YK_RG123/2013(H7N9)), Homo sapiens |
| Method: | XRD |
| Resolution (Å): | 3.50 |
| Reference: | 10.1038/s41564-018-0303-7 |
| Antibody | |
| Antibody: | L3A-44 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Influenza A virus H7N9 hemagglutinin |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: P
Mutation: NULL
| >6II9_P|Chain G[auth H], I[auth M], K[auth P]|Heavy chain of L3A-44 Fab|Homo sapiens (9606) LQLQEWGAGLLKPSETLSLTCAVYGGSFSGYYWSWIRQPPGKGLEWIGEINHSGGTNYNPSLKSRVTISVDTSNNQFSLKLSSVTAADTAVYYCARGVWEGSGSDNFDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPK |
Light Chain: Q
Mutation: NULL
| >6II9_Q|Chain H[auth L], J[auth N], L[auth Q]|Light chain of L3A-44 Fab|Homo sapiens (9606) ALTQPPSVSGAPGQRVTISCTGSSSNIGAGFDVHWYQQLPGTAPKLLIYGNSFRPSGVPDRFSGSKSGTSASLAIAGLQAEDEADYYCQSYDSSLSGVVFGGGTKLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPT |
Antigen
Chain: E
Mutation: NULL
| >6II9_E|Chain A, C, E|Hemagglutinin|Influenza A virus (1386076) DKICLGHHAVSNGTKVNTLTERGVEVVNATETVERTNIPRICSKGKRTVDLGQCGLLGTITGPPQCDQFLEFSADLIIERREGSDVCYPGKFVNEEALRQILRESGGIDKEAMGFTYSGIRTNGATSACRRSGSSFYAEMKWLLSNTDNAAFPQMTKSYKNTRKSPALIVWGIHHSVSTAEQTKLYGSGNKLVTVGSSNYQQSFVPSPGARPQVNGLSGRIDFHWLMLNPNDTVTFSFNGAFIAPDRASFLRGKSMGIQSGVQVDANCEGDCYHSGGTIISNLPFQNIDSRAVGKCPRYVKQRSLLLATGMKNVPEI |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| P: GLY27 SER28 SER30 GLY31 TYR32 TYR33 ASN52 SER54 GLY56 ASN58 VAL99 TRP100 GLU101 GLY102 SER103 GLY104 Q: ALA31 GLY32 PHE33 ASP34 GLY52 ASN53 PHE55 TYR93 SER95 SER98 E: TYR88 ARG121 ASN123 GLY124 ALA125 THR126 SER127 ARG130 SER132 GLY133 SER134 TRP142 LEU144 ASP148 ASN149 VAL177 SER178 ALA180 GLU181 THR183 LYS184 LEU185 ALA210 GLN213 GLY216 LEU217 SER218 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
