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Entry information

Complex
AACDB_ID: 2320
PDBID: 6II9
Chains: HL_A
Organism: Influenza A virus (A/Anhui/DEWH72-02/2013(H7N9)), Influenza A virus (A/Anhui/1-YK_RG123/2013(H7N9)), Homo sapiens
Method: XRD
Resolution (Å): 3.50
Reference: 10.1038/s41564-018-0303-7
Antibody
Antibody: L3A-44 Fab
Antibody mutation: No
INN (Clinical Trial):
Antigen
Antigen: Influenza A virus H7N9 hemagglutinin
Antigen mutation: No
Durg Target:

Sequence information

Antibody

Heavy Chain: H
Mutation: NULL

>6II9_H|Chain G[auth H], I[auth M], K[auth P]|Heavy chain of L3A-44 Fab|Homo sapiens (9606)
LQLQEWGAGLLKPSETLSLTCAVYGGSFSGYYWSWIRQPPGKGLEWIGEINHSGGTNYNPSLKSRVTISVDTSNNQFSLKLSSVTAADTAVYYCARGVWEGSGSDNFDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPK

Light Chain: L
Mutation: NULL

>6II9_L|Chain H[auth L], J[auth N], L[auth Q]|Light chain of L3A-44 Fab|Homo sapiens (9606)
ALTQPPSVSGAPGQRVTISCTGSSSNIGAGFDVHWYQQLPGTAPKLLIYGNSFRPSGVPDRFSGSKSGTSASLAIAGLQAEDEADYYCQSYDSSLSGVVFGGGTKLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPT

Antigen

Chain: A
Mutation: NULL

>6II9_A|Chain A, C, E|Hemagglutinin|Influenza A virus (1386076)
DKICLGHHAVSNGTKVNTLTERGVEVVNATETVERTNIPRICSKGKRTVDLGQCGLLGTITGPPQCDQFLEFSADLIIERREGSDVCYPGKFVNEEALRQILRESGGIDKEAMGFTYSGIRTNGATSACRRSGSSFYAEMKWLLSNTDNAAFPQMTKSYKNTRKSPALIVWGIHHSVSTAEQTKLYGSGNKLVTVGSSNYQQSFVPSPGARPQVNGLSGRIDFHWLMLNPNDTVTFSFNGAFIAPDRASFLRGKSMGIQSGVQVDANCEGDCYHSGGTIISNLPFQNIDSRAVGKCPRYVKQRSLLLATGMKNVPEI

Interaction

1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.

Interacting residues (ΔSASA based)

H: SER28 SER30 GLY31 TYR32 TYR33 ASN52 SER54 THR57 ASN58 TYR59 VAL99 TRP100 GLU101 GLY102 SER103 GLY104

L: ALA31 GLY32 PHE33 ASP34 GLY52 ASN53 PHE55 TYR93 SER95 SER98

A: ARG121 ASN123 GLY124 ALA125 THR126 SER127 ARG130 SER132 GLY133 SER134 TRP142 LEU144 ASN146 THR147 ASP148 ASN149 VAL177 SER178 ALA180 GLU181 THR183 LYS184 LEU185 GLN213 GLY216 LEU217

2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.

Interacting residues (Atom distance based)

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