Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 2317 |
| PDBID: | 6II8 |
| Chains: | HL_C |
| Organism: | Influenza A virus (A/Anhui/DEWH72-02/2013(H7N9)), Influenza A virus (A/Anhui/1-YK_RG123/2013(H7N9)), Homo sapiens |
| Method: | XRD |
| Resolution (Å): | 3.32 |
| Reference: | 10.1038/s41564-018-0303-7 |
| Antibody | |
| Antibody: | L4B-18 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Influenza A virus H7N9 hemagglutinin |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: H
Mutation: NULL
| >6II8_H|Chain G, I[auth H], J|Heavy chain of L4B-18 Fab|Homo sapiens (9606) EVQLVESGGGLVQPGGSLRLSCAASGFTFSSYAMSWVRQAPGKGLEWVSAISGSGGSTYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCAKDRLLWFGELLFEGFDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKV |
Light Chain: L
Mutation: NULL
| >6II8_L|Chain H[auth I], K, L|Light chain of L4B-18 Fab|Homo sapiens (9606) NFMLTQPHSVSESPGKTVTISCTRSSGSIASNYVQWYQQRPGSSPTTVIYEDNQRPSGVPDRFSGSIDSSSNSASLTISGLKTEDEADYYCQSYDSSNVVFGGGTKLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPT |
Antigen
Chain: C
Mutation: NULL
| >6II8_C|Chain A, C, E|Hemagglutinin|Influenza A virus (1386076) DKICLGHHAVSNGTKVNTLTERGVEVVNATETVERTNIPRICSKGKRTVDLGQCGLLGTITGPPQCDQFLEFSADLIIERREGSDVCYPGKFVNEEALRQILRESGGIDKEAMGFTYSGIRTNGATSACRRSGSSFYAEMKWLLSNTDNAAFPQMTKSYKNTRKSPALIVWGIHHSVSTAEQTKLYGSGNKLVTVGSSNYQQSFVPSPGARPQVNGLSGRIDFHWLMLNPNDTVTFSFNGAFIAPDRASFLRGKSMGIQSGVQVDANCEGDCYHSGGTIISNLPFQNIDSRAVGKCPRYVKQRSLLLATGMKNVPE |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| H: TYR51 SER71 SER73 GLY75 SER76 TYR78 LEU121 TRP122 PHE123 GLY124 GLU125 LEU126 LEU127 L: ARG43 GLY46 SER47 ALA49 SER50 ASN51 TYR52 GLU70 ASP71 ILE86 ASP114 SER115 C: ARG121 GLY124 ALA125 THR126 SER127 ALA128 ARG130 GLY133 SER134 TRP142 LEU144 SER145 ASN146 THR147 ASP148 ASN149 ALA150 SER178 ALA180 GLU181 LYS184 LEU185 GLN213 ASN215 GLY216 LEU217 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
