Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 2316 |
| PDBID: | 6II4 |
| Chains: | EF_C |
| Organism: | Influenza A virus (A/Anhui/DEWH72-02/2013(H7N9)), Influenza A virus (A/Anhui/1-YK_RG123/2013(H7N9)), Homo sapiens |
| Method: | XRD |
| Resolution (Å): | 3.30 |
| Reference: | 10.1038/s41564-018-0303-7 |
| Antibody | |
| Antibody: | L4A-14 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Influenza A virus H7N9 hemagglutinin |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: E
Mutation: NULL
| >6II4_E|Chain E, G[auth H]|Heavy chain of L4A-14 Fab|Homo sapiens (9606) EVQLLESGGGVVQPGRSLRLSCAASGFTFSSYAIHWVRQAPGKGLEWVALISYDGSNKYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCNGHGSGGEVGSNWFDPWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKS |
Light Chain: F
Mutation: NULL
| >6II4_F|Chain F, H[auth L]|Light chain of L4A-14 Fab|Homo sapiens (9606) NFMLTQPHSVSESPGKTVTISCTRSSGSIASNYVQWYQQRPGSSPTTVIYEYNQRPSGVPDRFSGSIDSSSNSASLTISGLKTEDEADYYCQSYDSANRVFGGGTKLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAP |
Antigen
Chain: C
Mutation: NULL
| >6II4_C|Chain A, C|Hemagglutinin|Influenza A virus (1386076) DKICLGHHAVSNGTKVNTLTERGVEVVNATETVERTNIPRICSKGKRTVDLGQCGLLGTITGPPQCDQFLEFSADLIIERREGSDVCYPGKFVNEEALRQILRESGGIDKEAMGFTYSGIRTNGATSACRRSGSSFYAEMKWLLSNTDNAAFPQMTKSYKNTRKSPALIVWGIHHSVSTAEQTKLYGSGNKLVTVGSSNYQQSFVPSPGARPQVNGLSGRIDFHWLMLNPNDTVTFSFNGAFIAPDRASFLRGKSMGIQSGVQVDANCEGDCYHSGGTIISNLPFQNIDSRAVGKCPRYVKQRSLLLATGMKNVPEI |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| E: SER31 ALA33 HIS35 LEU50 SER52 TYR53 ASP54 SER56 ASN57 TYR59 HIS99 GLY100 SER101 GLY102 GLY103 GLU104 VAL105 GLY106 SER107 TRP109 F: ALA30 SER31 ASN32 TYR33 GLU51 TYR52 TYR94 SER96 ALA97 C: TYR88 GLY119 ILE120 ARG121 ASN123 GLY124 ALA125 THR126 SER127 SER134 TRP142 LEU144 ASN146 THR147 ASP148 ASN149 ALA150 ALA151 SER178 THR179 ALA180 GLU181 THR183 LYS184 LEU185 SER188 LEU217 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
