Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 2308 |
| PDBID: | 6IEC |
| Chains: | CD_B |
| Organism: | Rift Valley fever virus, Homo sapiens |
| Method: | XRD |
| Resolution (Å): | 3.20 |
| Reference: | 10.1038/s41564-019-0411-z |
| Antibody | |
| Antibody: | R17 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Rift Valley fever virus (RVFV) NSmGnGc gp |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: C
Mutation: NULL
| >6IEC_C|Chain B[auth C], E[auth F], H, K[auth J]|R17 H chain|Homo sapiens (9606) QVQLVQSGGGLVKPGGSLRLSCAASGFTFSDYYMSWIRQAPGKGLEWVSYISPGGSTIYYADSVKGRFTISRDNAKNSLYLQMNSLRAEDTAVYYCASSADVYNWFDPWGQGTLV |
Light Chain: D
Mutation: NULL
| >6IEC_D|Chain C[auth D], F[auth G], I[auth K], L|R17 L chain|Homo sapiens (9606) SYELTQPPSVSVAPGKTARITCGGNNIGSKSVHWYQQKPGQAPVLVVYDDSDRPSGIPERFSGSNSGNTATLTISRVEAGDEADYYCQVWDSSSDHLYVFGTGTKVTVLGQ |
Antigen
Chain: B
Mutation: NULL
| >6IEC_B|Chain A, D[auth B], G[auth E], J[auth I]|NSmGnGc|Rift valley fever virus (11588) EDPHLRNRPGKGHNYIDGMTQEDATCKPVTYAGACSSFDVLLEKGKFPLFQSYAHHRTLLEAVHDTIIAKADPPSCDLQSAHGNPCMKEKLVMKTHCPNDYQSAHYLNNDGKMASVKCPPKYELTEDCNFCRQMTGASLKKGSYPLQDLFCQSSEDDGSKLKTKMKGVCEVGVQALKKCDGQLSTAHEVVPFAVFKNSKKVYLDKLDLKTEENLLPDSFVCFEHKGQYKGTIDSGQTKRELKSFDISQCPKIGGHGSKKCTGDAAFCSAYECTAQYANAYCSHANGSGIVQIQVSGVWKKPLCVGYERVVVKRELS |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| C: ASP31 TYR33 SER52 PRO53 GLY54 SER56 THR57 TYR59 ALA100 ASP101 VAL102 TYR103 ASN104 TRP105 D: ASN26 GLY28 SER29 LYS30 SER31 TYR48 ASP49 ASP50 ASP52 ASN65 TRP90 SER92 B: ASP17 GLY18 THR20 GLN21 LYS70 ASP72 PRO73 PRO74 SER75 ASP77 GLN79 SER80 ALA81 PRO85 GLN102 LYS117 CYS118 PRO119 PRO120 LYS121 TYR122 GLN133 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
