Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 2306 |
| PDBID: | 6IEB |
| Chains: | HL_A |
| Organism: | Homo sapiens, Rift Valley fever virus |
| Method: | XRD |
| Resolution (Å): | 2.41 |
| Reference: | 10.1038/s41564-019-0411-z |
| Antibody | |
| Antibody: | R15 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Rift Valley fever virus (RVFV) NSmGnGc gp |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: H
Mutation: NULL
| >6IEB_H|Chain A[auth E], E[auth H]|R15 H chain|Homo sapiens (9606) QVQLQESGPGLVKPSETLSLTCTVSGGSISTYYWSWIRQPPGKGLEWIGYIYYSGSTNYNPSLKTRVTISVDTSKNQFSLKLSSVTAADTAVYYCARSDYGDLIFDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEP |
Light Chain: L
Mutation: NULL
| >6IEB_L|Chain B[auth F], F[auth L]|R15 L chain|Homo sapiens (9606) LPVLTQPPSVSVSPGQTASITCSGDKLGDKYVCWYQQKPGQSPVLVIYQDSKRPSGIPERFSGSNSGNTATLTISGTQAMDEADYYCQACDSSTVFGGGTKLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAP |
Antigen
Chain: A
Mutation: NULL
| >6IEB_A|Chain C[auth A], D[auth B]|NSmGnGc|Rift valley fever virus (11588) EDPHLRNRPGKGHNYIDGMTQEDATCKPVTYAGACSSFDVLLEKGKFPLFQSYAHHRTLLEAVHDTIIAKADPPSCDLQSAHGNPCMKEKLVMKTHCPNDYQSAHYLNNDGKMASVKCPPKYELTEDCNFCRQMTGASLKKGSYPLQDLFCQSSEDDGSKLKTKMKGVCEVGVQALKKCDGQLSTAHEVVPFAVFKNSKKVYLDKLDLKTEENLLPDSFVCFEHKGQYKGTIDSGQTKRELKSFDISQCPKIGGHGSKKCTGDAAFCSAYECTAQYANAYCSHANGSGIVQIQVSGVWKKPLCVGYERVVVKRELS |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| H: THR31 TYR33 TYR50 TYR52 TYR53 SER54 SER56 THR73 TYR100 GLY101 ASP102 L: GLY28 ASP29 LYS30 TYR31 GLN49 ASP50 LYS52 ASN65 ASP91 SER92 A: THR20 GLN21 GLU22 ASP23 ALA24 THR25 LYS27 PRO28 THR30 ALA32 GLY33 ALA34 PRO120 LYS121 MET134 ALA137 SER138 LEU139 LYS141 LYS242 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
