Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 2305 |
| PDBID: | 6IEA |
| Chains: | HL_A |
| Organism: | Rift Valley fever virus, Homo sapiens |
| Method: | XRD |
| Resolution (Å): | 2.00 |
| Reference: | 10.1038/s41564-019-0411-z |
| Antibody | |
| Antibody: | R13 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Rift Valley fever virus (RVFV) NSmGnGc gp |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: H
Mutation: NULL
| >6IEA_H|Chain C[auth H]|R13 H chain|Homo sapiens (9606) QVQLQESGPGLVKPSQTLSLTCTVSGGSISSGGYYWSWIRQHPGKGLEWIGYIYDSGSTYYNPSLKSRVTISVDTSKNQFSLKLSSVTAADTALYYCASLPYCSGRICRPRTDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEP |
Light Chain: L
Mutation: NULL
| >6IEA_L|Chain B[auth L]|R13 L chain|Homo sapiens (9606) LPVLTQPPSSSASPGESARLTCTLPSDINVGSYNIYWYQQKPGSPPRYLLYYYSDSDKGQGSGVPSRFSGSKDASANTGILLISGLQSEDEADYYCMIWPSNAWVFGGGTKLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPT |
Antigen
Chain: A
Mutation: NULL
| >6IEA_A|Chain A|NSmGnGc|Rift valley fever virus (11588) EDPHLRNRPGKGHNYIDGMTQEDATCKPVTYAGACSSFDVLLEKGKFPLFQSYAHHRTLLEAVHDTIIAKADPPSCDLQSAHGNPCMKEKLVMKTHCPNDYQSAHYLNNDGKMASVKCPPKYELTEDCNFCRQMTGASLKKGSYPLQDLFCQSSEDDGSKLKTKMKGVCEVGVQALKKCDGQLSTAHEVVPFAVFKNSKKVYLDKLDLKTEENLLPDSFVCFEHKGQYKGTIDSGQTKRELKSFDISQCPKIGGHGSKKCTGDAAFCSAYECTAQYANAYCSHANGSGIVQIQVSGVWKKPLCVGYERVVVKRELS |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| L: ASN29 GLY31 SER32 TYR33 ASN34 TYR53 SER54 ASP55 ASP57 ALA74 TRP99 PRO100 SER101 H: TYR35 TYR54 TYR102 CYS103 SER104 GLY105 ARG106 ILE107 ARG109 A: HIS13 GLY18 THR20 GLN21 GLU22 ASP23 ALA24 THR25 LYS27 PRO28 ALA32 GLY33 ALA34 GLN102 PRO120 LYS121 ALA137 SER138 LEU139 LYS140 LYS141 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
