Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 2302 |
| PDBID: | 6IAP |
| Chains: | HL_A |
| Organism: | Homo sapiens, synthetic construct |
| Method: | XRD |
| Resolution (Å): | 2.90 |
| Reference: | 10.1016/j.cell.2019.04.041 |
| Antibody | |
| Antibody: | NKp46-1 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Natural cytotoxicity triggering receptor 1 |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: H
Mutation: NULL
| >6IAP_H|Chain D[auth H]|Fab NKp46-1 heavy chain|synthetic construct (32630) QVQLVQSGAEVKKPGSSVKVSCKASGYTFSDYVINWVRQAPGQGLEWMGEIYPGSGTNYYNEKFKAKATITADKSTSTAYMELSSLRSEDTAVYYCARRGRYGLYAMDYWGQGTTVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEP |
Light Chain: L
Mutation: NULL
| >6IAP_L|Chain E[auth L]|Fab NKp46-1 light chain|synthetic construct (32630) DIQMTQSPSSLSASVGDRVTITCRASQDISNYLNWYQQKPGKAPKLLIYYTSRLHSGVPSRFSGSGSGTDFTFTISSLQPEDIATYFCQQGNTRPWTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNR |
Antigen
Chain: A
Mutation: NULL
| >6IAP_A|Chain A|Natural cytotoxicity triggering receptor 1|Homo sapiens (9606) TLPKPFIWAEPHFMVPKEKQVTICCQGNYGAVEYQLHFEGSLFAVDRPKPPERINKVKFYIPDMNSRMAGQYSCIYRVGELWSEPSNLLDLVVTEMYDTPTLSVHPGPEVISGEKVTFYCRLDTATSMFLLLKEGRSSHVQRGYGKVQAEFPLGPVTTAHRGTYRCFGSYNNHAWSFPSEPV |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| H: TYR27 THR28 SER30 ASP31 TYR32 VAL33 TYR52 PRO53 GLY54 SER55 TYR59 ARG98 ARG99 GLY100 ARG101 TYR102 GLY103 LEU104 TYR105 L: TYR32 TYR50 ARG53 ARG94 A: LYS17 GLU18 ASP63 ASN65 SER66 ARG67 GLU95 MET96 TYR97 ASP98 THR99 THR101 LEU122 ASP123 THR124 TYR170 PHE177 GLU180 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
