Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 2300 |
| PDBID: | 6I9I |
| Chains: | HL_A |
| Organism: | Oryctolagus cuniculus, Rift Valley fever virus |
| Method: | XRD |
| Resolution (Å): | 1.98 |
| Reference: | 10.1016/j.celrep.2018.12.001 |
| Antibody | |
| Antibody: | RV-Gn1 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Rift valley fever virus Glycoprotein |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: H
Mutation: NULL
| >6I9I_H|Chain A, E[auth H]|RV-Gn1 Heavy chain|Oryctolagus cuniculus (9986) TGSLEESGGRLVTPGTPLTLTCTVSGIDPNSDHMSWVRQAPGKGLEWIAIIYASGTTYYASWAKGRFTISKTSTTVDLRIASPTTEDTATYFCATYPNYPTDNLWGQGTLVTVSGTQPKAPSVFPLAPCCGDTPSSTVTLGCLVKGYLPEPVTVTWNSGTLTNGVRTFPSVRQSSGLYSLSSVVSVTSSSQPVTCNVAHPATNTKVDKTVAPSTCSKHHHHHH |
Light Chain: L
Mutation: NULL
| >6I9I_L|Chain B, F[auth L]|RV-Gn1 Light chain|Oryctolagus cuniculus (9986) TGMTQTPSPVSAAVGGTVTINCQASQSVYNNYLLSWYQQKPGQPPKRLIYSASTLASGVSSRFKGSGSGTQFTLTISDVQCDDAATYYCLGSYDGNSADCLAFGGGTEVVVKGTPVAPTVLIFPPAADQVATGTVTIVCVANKYFPDVTVTWEVDGTTQTTGIENSKTPQNSADCTYNLSSTLTLTSTQYNSHKEYTCKVTQGTTSVVQSFNRGDCS |
Antigen
Chain: A
Mutation: NULL
| >6I9I_A|Chain A, E[auth H]|RV-Gn1 Heavy chain|Oryctolagus cuniculus (9986) TGSLEESGGRLVTPGTPLTLTCTVSGIDPNSDHMSWVRQAPGKGLEWIAIIYASGTTYYASWAKGRFTISKTSTTVDLRIASPTTEDTATYFCATYPNYPTDNLWGQGTLVTVSGTQPKAPSVFPLAPCCGDTPSSTVTLGCLVKGYLPEPVTVTWNSGTLTNGVRTFPSVRQSSGLYSLSSVVSVTSSSQPVTCNVAHPATNTKVDKTVAPSTCSKHHHHHH |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| H: SER61 TRP62 LYS64 ARG66 THR83 GLU85 L: SER26 GLN27 A: LYS43 SER61 TRP62 LYS64 GLY65 ARG66 THR83 THR84 GLU85 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
