Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 23 |
| PDBID: | 1DVF |
| Chains: | BA_D |
| Organism: | Mus musculus |
| Method: | XRD |
| Resolution (Å): | 1.90 |
| Reference: | 10.1006/jmbi.1996.0629 |
| Antibody | |
| Antibody: | anti-idiotype E5.2 Fv |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | D1.3 Fv heavy chain |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: B
Mutation: NULL
| >1DVF_B|Chain B|FV D1.3|Mus musculus (10090) QVQLQESGPGLVAPSQSLSITCTVSGFSLTGYGVNWVRQPPGKGLEWLGMIWGDGNTDYNSALKSRLSISKDNSKSQVFLKMNSLHTDDTARYYCARERDYRLDYWGQGTTLTVSS |
Light Chain: A
Mutation: NULL
| >1DVF_A|Chain A|FV D1.3|Mus musculus (10090) DIVLTQSPASLSASVGETVTITCRASGNIHNYLAWYQQKQGKSPQLLVYYTTTLADGVPSRFSGSGSGTQYSLKINSLQPEDFGSYYCQHFWSTPRTFGGGTKLEIKR |
Antigen
Chain: D
Mutation: NULL
| >1DVF_D|Chain D|FV E5.2|Mus musculus (10090) QVQLQQSGTELVKSGASVKLSCTASGFNIKDTHMNWVKQRPEQGLEWIGRIDPANGNIQYDPKFRGKATITADTSSNTAYLQLSSLTSEDTAVYYCATKVIYYQGRGAMDYWGQGTTLTVS |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| A: TYR32 TYR49 TYR50 THR53 ASP56 PHE91 TRP92 B: THR30 GLY31 TYR32 GLY33 TRP52 GLY53 ASP54 ASN56 THR57 ASP58 GLU98 ARG99 ASP100 TYR101 ARG102 D: LYS30 ASP31 HIS33 ARG50 ALA53 ASN54 ASN56 GLN58 LYS95 VAL96 ILE97 TYR98 TYR99 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
