Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 2299 |
| PDBID: | 6I9I |
| Chains: | AB_C |
| Organism: | Oryctolagus cuniculus, Rift Valley fever virus |
| Method: | XRD |
| Resolution (Å): | 1.98 |
| Reference: | 10.1016/j.celrep.2018.12.001 |
| Antibody | |
| Antibody: | RV-Gn1 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Rift valley fever virus Glycoprotein |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: A
Mutation: NULL
| >6I9I_A|Chain A, E[auth H]|RV-Gn1 Heavy chain|Oryctolagus cuniculus (9986) TGSLEESGGRLVTPGTPLTLTCTVSGIDPNSDHMSWVRQAPGKGLEWIAIIYASGTTYYASWAKGRFTISKTSTTVDLRIASPTTEDTATYFCATYPNYPTDNLWGQGTLVTVSGTQPKAPSVFPLAPCCGDTPSSTVTLGCLVKGYLPEPVTVTWNSGTLTNGVRTFPSVRQSSGLYSLSSVVSVTSSSQPVTCNVAHPATNTKVDKTVAPSTCSKHHHHHH |
Light Chain: B
Mutation: NULL
| >6I9I_B|Chain B, F[auth L]|RV-Gn1 Light chain|Oryctolagus cuniculus (9986) TGMTQTPSPVSAAVGGTVTINCQASQSVYNNYLLSWYQQKPGQPPKRLIYSASTLASGVSSRFKGSGSGTQFTLTISDVQCDDAATYYCLGSYDGNSADCLAFGGGTEVVVKGTPVAPTVLIFPPAADQVATGTVTIVCVANKYFPDVTVTWEVDGTTQTTGIENSKTPQNSADCTYNLSSTLTLTSTQYNSHKEYTCKVTQGTTSVVQSFNRGDCS |
Antigen
Chain: C
Mutation: NULL
| >6I9I_C|Chain C, D|Glycoprotein|Rift valley fever virus (11588) EDPHLRNRPGKGHNYIDGMTQEDATCKPVTYAGACSSFDVLLEKGKFPLFQSYAHHRTLLEAVHDTIIAKADPPSCDLQSAHGNPCMKEKLVMKTHCPNDYQSAHYLNNDGKMASVKCPPKYELTEDCNFCRQMTGASLKKGSYPLQDLFCQSSEDDGSKLKTKMKGVCEVGVQALKKCDGQLSTAHEVVPFAVFKNSKKVYLDKLDLKTEENLLPDSFVCFEHKGQYKGTMDSGQTKRELKSFDISQCPKIGGHGSKKCTGDAAFCSAYECTAQYANAYCSHANGSGIVQIQVSGVWKKPLCVGYERVVVKRELSGTKHHHHHH |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| A: THR1 GLY26 ILE27 ASP28 ASN30 SER31 ASP32 HIS33 TYR52 ALA53 SER54 THR56 TYR58 TYR95 ASN97 TYR98 PRO99 B: TYR31 LEU32 TYR49 SER50 SER91 TYR92 ASP93 GLY94 CYS95 LEU96 C: SER400 GLN401 PRO403 LYS404 ILE405 GLY406 GLY407 HIS408 GLY409 SER410 LYS411 LYS412 GLU424 CYS425 THR426 ALA427 GLN428 TYR429 ASN431 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
