Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 2292 |
| PDBID: | 6I6J |
| Chains: | C_A |
| Organism: | Gallus gallus, synthetic construct |
| Method: | XRD |
| Resolution (Å): | 2.23 |
| Reference: | 10.1126/science.aaw2859 |
| Antibody | |
| Antibody: | 6I6J synthetic-Nanobody |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | ER lumen protein-retaining receptor 2 |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Chain: C
Mutation: NULL
| >6I6J_C|Chain B[auth C]|Sybody|synthetic construct (32630) QVQLVESGGGLVQAGGSLRLSCAASGFPVKRWSMTWYRQAPGKEREWVAAIRSAGHWTHYADSVKGRFTISRDNAKNTVYLQMNSLKPEDTAVYYCNVKDEGDFSYWYDYWGQGTQVTVSA |
Antigen
Chain: A
Mutation: NULL
| >6I6J_A|Chain A|ER lumen protein-retaining receptor 2|Gallus gallus (9031) MNIFRLTGDLSHLAAIIILLLKIWKSRSCAGISGKSQLLFALVFTTRYLDLFTSFISLYNTSMKLIYIACSYATVYLIYMKFKATYDGNHDTFRVEFLIVPVGGLSFLVNHDFSPLEILWTFSIYLESVAILPQLFMISKTGEAETITTHYLFFLGLYRALYLVNWIWRYYFEGFFDLIAVVAGVVQTVLYCDFFYLYVTKVLK |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| C: GLN2 VAL30 LYS31 ARG32 SER34 THR36 TYR38 TRP48 ALA51 ARG53 ALA55 GLY56 HIS57 TRP58 HIS60 LYS100 ASP101 GLU102 GLY103 ASP104 PHE105 SER106 TYR107 TRP108 TYR109 A: MET1 ASN2 ARG5 LEU6 ASP9 ARG47 TYR48 ASP50 THR53 SER54 PHE55 ILE56 TYR59 ASN60 MET63 LYS64 TYR67 HIS111 ASP112 LEU116 GLU117 TRP120 TYR162 ARG169 TYR170 TYR171 PHE172 GLU173 GLY174 PHE175 PHE176 ASP177 LEU178 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
