Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 2283 |
| PDBID: | 6HX4 |
| Chains: | HL_B |
| Organism: | Homo sapiens, Mus musculus |
| Method: | XRD |
| Resolution (Å): | 2.95 |
| Reference: | Not available or To be published |
| Antibody | |
| Antibody: | 1D9 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Alpha-1-antitrypsin |
| Antigen mutation: | No |
| Durg Target: | P01009 |
Sequence information
Antibody
Heavy Chain: H
Mutation: NULL
| >6HX4_H|Chain C[auth H], E[auth I]|Fab 1D9 heavy chain|Mus musculus (10090) DVQLVESGGGLVKPGGSLKLSCAASGFTFSSYTMSWVRQTPEKRLEWVATISSGGDYTYSPDSVKGRFTISRDNAKSTLYLQMSSLKSEDTAMFYCSRAEFITTATWGVYAMDYWGQGTSVTVSSAKTTPPSVYPLAPGSAAQTNSMVTLGCLVKGYFPEPVTVTWNSGSLSSGVHTFPAVLQSDLYTLSSSVTVPSSTWPSETVTCNVAHPASSTKVDKKIVPRDCD |
Light Chain: L
Mutation: NULL
| >6HX4_L|Chain D[auth L], F[auth M]|Fab 1D9 light chain|Mus musculus (10090) DIVLTQSPDSLAVSLGQRATISCRASESVDNYGISFMNWFQQKPGQPPKLLIYAASNQGSGVPARFSGSGSGTDFSLNIHPMEEDDTAMYFCQQSKEVPWTFGGGTKLEIKRADAAPTVSIFPPSSEQLTSGGASVVCFLNNFYPKDINVKWKIDGSERQNGVLNSWTDQDSKDSTYSMSSTLTLTKDEYERHNSYTCEATHKTSTSPIVKSFNRNE |
Antigen
Chain: B
Mutation: NULL
| >6HX4_B|Chain A, B|Alpha-1-antitrypsin|Homo sapiens (9606) MRGSDPQGDAAQKTDTSHHDQDHPTFNKITPNLAEFAFSLYRQLAHQSNSTNIFFSPVSIATAFAMLSLGTKADTHDEILEGLNFNLTEIPEAQIHEGFQELLRTLNQPDSQLQLTTGNGLFLSEGLKLVDKFLEDVKKLYHSEAFTVNFGDTEEAKKQINDYVEKGTQGKIVDLVKELDRDTVFALVNYIFFKGKWERPFEVKDTEEEDFHVDQVTTVKVPMMKRLGMFNIQHCKKLSSWVLLMKYLGNATAIFFLPDEGKLQHLENELTHDIITKFLENEDRRSASLHLPKLSITGTYDLKSVLGQLGITKVFSNGADLSGVTEEAPLKLSKAVHKAVLTIDEKGTEAAGAMFLEAIPMSIPPEVKFNKPFVFLMIEQNTKSPLFMGKVVNPTQK |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| H: THR28 SER30 SER31 TYR32 THR33 THR50 SER52 GLY53 ASP55 TYR56 TYR58 GLU96 PHE97 THR99 L: TYR28 SER91 LYS92 GLU93 VAL94 TRP96 B: ASP207 HIS209 GLN212 LYS222 LEU224 MET226 ILE229 GLN230 HIS231 LYS233 TRP238 ASP256 GLU257 ARG281 ARG282 SER283 SER285 HIS287 PRO357 MET358 SER359 ILE360 PRO361 PRO362 GLU363 LYS365 ASN367 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
