Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 2279 |
| PDBID: | 6HHC |
| Chains: | HL_A |
| Organism: | Homo sapiens |
| Method: | XRD |
| Resolution (Å): | 2.70 |
| Reference: | 10.1016/j.jmb.2019.09.008 |
| Antibody | |
| Antibody: | FXIA Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Coagulation factor XI |
| Antigen mutation: | No |
| Durg Target: | P03951 |
Sequence information
Antibody
Heavy Chain: H
Mutation: NULL
| >6HHC_H|Chain B[auth H]|FXIA ANTIBODY FAB HEAVY CHAIN|Homo sapiens (9606) EVQLLESGGGLVQPGGSLRLSCAASGFTFSQYGMDWVRQAPGKGLEWVSGIGPSGGSTVYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCTRGGPYYYYGMDVWGQGTTVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTH |
Light Chain: L
Mutation: NULL
| >6HHC_L|Chain A[auth L]|FXIA ANTIBODY FAB LIGHT CHAIN|Homo sapiens (9606) AQDIQMTQSPSSLSASVGDRVTITCQASQDISNYLNWYQQKPGKAPKLLIYDASNLETGVPSRFSGSGSGTDFTFTISSLQPEDIATYYCQQANSFPVTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYSREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC |
Antigen
Chain: A
Mutation: NULL
| >6HHC_A|Chain C[auth A]|Coagulation factor XI|Homo sapiens (9606) IVGGTASVRGEWPWQVTLHTTSPTQRHLCGGSIIGNQWILTAAHCFYGVESPKILRVYSGILNQSEIKEDTSFFGVQEIIIHDQYKMAESGYDIALLKLETTVNYTDSQRPISLPSKGDRNVIYTDCWVTGWGYRKLRDKIQNTLQKAKIPLVTNEECQKRYRGHKITHKMICAGYREGGKDACKGDSGGPLSCKHNEVWHLVGITSWGEGCAQRERPGVYTNVVEYVDWILEKTQAV |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| L: SER32 ASN33 TYR34 TYR51 ASP52 ASN55 THR58 ALA93 ASN94 SER95 PHE96 H: THR28 GLN31 TYR32 GLY33 MET34 ASP35 GLY50 ILE51 GLY52 PRO53 SER57 GLY99 GLY100 PRO101 TYR102 TYR103 TYR104 TYR105 A: HIS406 PRO410 THR411 GLN412 ARG413 HIS414 ASN450 GLN451 SER452 ILE454 LYS455 ARG522 LYS523 LEU524 ARG525 ASP526 LYS527 ILE528 GLN529 ASN530 THR531 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
