Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 2278 |
| PDBID: | 6HGA |
| Chains: | HL_B |
| Organism: | Homo sapiens, Mus musculus |
| Method: | XRD |
| Resolution (Å): | 2.60 |
| Reference: | 10.1016/j.immuni.2020.02.004 |
| Antibody | |
| Antibody: | anti-APP Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Interleukin-17 receptor C |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: H
Mutation: NULL
| >6HGA_H|Chain B[auth H]|anti-APP-tag Fab heavy-chain|Mus musculus (10090) QVTLKESGPGILQPSQTLSLTCSFSGFSLSTSGMGVSWIRQPSGKGLEWLAHIYWDNDRYYNPSLKSRLTISKDTFSNQVFLKITNVDTADTATYYCARSPMNTWGDYWGQGTSVTVSSAKTTAPSVYPLAPVCGDTTGSSVTLGCLVKGYFPEPVTLTWNSGSLSSGVHTFPAVLQSDLYTLSSSVTVTSSTWPSQSITCNVAHPASSTKVDKKIEPRGPT |
Light Chain: L
Mutation: NULL
| >6HGA_L|Chain C[auth L]|anti-APP-tag Fab light-chain|Mus musculus (10090) DVVMTQTPLSLPVSLGDQASISCRSSQSLVHSNGNTYLHWYLQKPGQSPKLLIYKVSNRFSGVPDRFSGSGSGTDFTLKISRVEAEDLGIYFCSQNTHVPLTFGAGTKLELKRADAAPTVSIFPPSSEQLTSGGASVVCFLNNFYPKDINVKWKIDGSERQNGVLNSWTDQDSKDSTYSMSSTLTLTKDEYERHNSYTCEATHKTSTSPIVKSFNRNEC |
Antigen
Chain: B
Mutation: NULL
| >6HGA_B|Chain A[auth B]|Interleukin-17 receptor C|Homo sapiens (9606) ALPWLNVSADGDNVHLVLNVSEEQHFGLSLYWNQVQGPPKPRWHKNLTGPQIITLQHTDLVPCLCIQVWPLEPDSVRTNICPFREDPRAHQNLWQAARLRLLTLQSWLLDAPCSLPAEAALCWRAPGGDPCQPLVPPLSWEQVTVDKVLEFPLLKGHPNLCVQVQSSEKLQLQECLWADSLGPLKDDVLLLETRGPQDQRSLCALEPSGCTSLPSKASTRAARLGEYLLQDLQSGQCLQLWDDDLGALWACPMDKYIHKREFRH |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| H: HIS52 TYR54 TRP55 ASP56 ASP58 TYR60 MET102 TRP105 L: ASP1 VAL2 SER25 SER26 GLN27 SER28 VAL30 HIS31 SER32 ASN33 GLY34 TYR37 SER72 GLY73 THR74 ASP75 ASN96 THR97 HIS98 VAL99 LEU101 B: SER422 LYS423 ALA424 SER425 ALA429 ARG430 LEU431 GLU433 TYR434 LYS466 ARG467 GLU468 PHE469 ARG470 HIS471 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
