Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 2269 |
| PDBID: | 6H70 |
| Chains: | D_A |
| Organism: | Norovirus Hu/1968/US, Vicugna pacos |
| Method: | XRD |
| Resolution (Å): | 1.83 |
| Reference: | 10.1128/JVI.02005-18 |
| Antibody | |
| Antibody: | Nano-62 Nanobody |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Norovirus Capsid protein VP1 |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Chain: D
Mutation: NULL
| >6H70_D|Chain C, D|Nanobody (VHH) Nano-62|Vicugna pacos (30538) QVQLQESGGGLVMTGGSLRLSCAVSGRTIDVSVMAWFRQAPGKEREFVSGMRWSGMTTYSADSVKDRFTISRDKTKNTVYLQMNSLKPEDTAVYYCAARSRFIVGVPQARDLYDYWGQGTQVTVSSGRYPYDVPDYGSGRA |
Antigen
Chain: A
Mutation: NULL
| >6H70_A|Chain A, B|Capsid protein VP1|Norwalk virus (strain GI/Human/United States/Norwalk/1968) (524364) KTRPFTLPNLPLSSLSNSRAPLPISSIGISPDNVQSVQFQNGRCTLDGRLVGTTPVSLSHVAKIRGTSNGTVINLTELDGTPFHPFEGPAPIGFPDLGGCDWHINMTQFGHSSQTQYDVDTTPDTFVPHLGSIQANGIGSGNYVGVLSWISPPSHPSGSQVDLWKIPNYGSSITEATHLAPSVYPPGFGEVLVFFMSKMPGPGAYNLPCLLPQEYISHLASEQAPTVGEAALLHYVDPDTGRNLGEFKAYPDGFLTCVPNGASSGPQQLPINGVFVFVSWVSRFYQLKPVGT |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| D: GLN1 GLN3 VAL24 SER25 GLY26 ARG27 THR28 ILE29 ASP30 ASN77 ARG99 SER100 ARG101 PHE102 ASP114 TYR115 A: ASP273 GLY274 ARG275 LEU276 VAL277 GLY278 THR280 GLU303 THR307 HIS310 GLU313 GLY314 ILE318 HIS404 LEU405 ALA406 PRO407 ALA446 GLN449 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
