Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 2266 |
| PDBID: | 6H6Y |
| Chains: | H_F |
| Organism: | Norovirus Hu/1968/US, Vicugna pacos |
| Method: | XRD |
| Resolution (Å): | 1.58 |
| Reference: | 10.1128/JVI.02005-18 |
| Antibody | |
| Antibody: | Nano-7 Nanobody |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Norovirus Capsid protein VP1 |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Chain: H
Mutation: NULL
| >6H6Y_H|Chain E, F, G, H|Nanobody (VHH) Nano-7|Vicugna pacos (30538) QVQLQESGGGLVQAGGSLRLSCAVSGRTFSNYYSGWFRQAPGKEREFLASIRWSDSTTNYADSVKGRFTISRDTAKNTVYLQMNSLKLEDTAVYHCAARRLATYDYWGQGTQVTVSSGRYPYDVPDYGSGRA |
Antigen
Chain: F
Mutation: NULL
| >6H6Y_F|Chain E, F, G, H|Nanobody (VHH) Nano-7|Vicugna pacos (30538) QVQLQESGGGLVQAGGSLRLSCAVSGRTFSNYYSGWFRQAPGKEREFLASIRWSDSTTNYADSVKGRFTISRDTAKNTVYLQMNSLKLEDTAVYHCAARRLATYDYWGQGTQVTVSSGRYPYDVPDYGSGRA |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| H: GLN39 ALA40 PRO41 GLY42 ARG45 VAL93 HIS95 GLN109 GLN112 THR114 F: GLY9 GLY10 LEU11 GLN13 THR91 GLN112 THR114 VAL115 SER116 SER117 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
