Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 2256 |
| PDBID: | 6H2Y |
| Chains: | HL_D |
| Organism: | Neisseria meningitidis, Homo sapiens |
| Method: | XRD |
| Resolution (Å): | 2.65 |
| Reference: | 10.1096/fj.201900374R |
| Antibody | |
| Antibody: | 1E6 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Lipoprotein GNA1870 |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: H
Mutation: NULL
| >6H2Y_H|Chain B[auth H]|Heavy chain|Homo sapiens (9606) EVQLVQSGAEVKKPGSSVKVSCKASGGTVIDYPITWVRQAPGQGLEWVGGFVPLFRTSNYGQKFQGRVTITADKSTSTASMELNSLTSEDTAIYYCARGDTAMGPFDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDK |
Light Chain: L
Mutation: NULL
| >6H2Y_L|Chain C[auth L]|Light chain|Homo sapiens (9606) VVSYVLTQPPSLSVAPGKTATLTCGGNNIAGKTVHWYQQRPGQAPVLVISYDSDRPSGIPERFSGSNSANTATLTISRVEAGDEADYYCQVWDRNSDHWVFGGGTKLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS |
Antigen
Chain: D
Mutation: NULL
| >6H2Y_D|Chain A[auth D]|Lipoprotein GNA1870|Neisseria meningitidis (487) MGPDSDRLQQRRVAADIGTGLADALTAPLDHKDKGLKSLTLEDSIPQNGTLTLSAQGAEKTFKAGDKDNSLNTGKLKNDKISRFDFVQKIEVDGQTITLASGEFQIYKQNHSAVVALQIEKINNPDKTDSLINQRSFLVSGLGGEHTAFNQLPGGKAEYHGKAFSSDDPNGRLHYSIDFTKKQGYGRIEHLKTLEQNVELAAAELKADEKSHAVILGDTRYGSEEKGTYHLALFGDRAQEIAGSATVKIGEKVHEIGIAGKQKLAAALEHHHHHH |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| H: ILE30 ASP31 TYR32 PRO33 PRO53 LEU54 PHE55 ARG56 ASN59 ASP100 THR101 ALA102 MET103 L: ALA28 GLY29 LYS30 THR31 TYR49 ASP50 SER51 ASP52 ARG53 ASN65 SER66 ALA67 TRP90 ARG92 ASN93 ASP95 D: THR51 SER53 ALA54 GLN55 GLY56 ALA57 GLU58 LYS79 ARG82 PHE83 ASP84 PHE85 VAL86 LYS88 THR97 SER100 GLY101 GLU102 GLN117 GLU119 LYS120 LEU130 ASN132 ARG134 ASP166 PRO168 ASN169 LYS191 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
