Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 2247 |
| PDBID: | 6GLW |
| Chains: | CD_B |
| Organism: | Homo sapiens, Lama glama |
| Method: | XRD |
| Resolution (Å): | 1.90 |
| Reference: | 10.1126/science.aaw4295 |
| Antibody | |
| Antibody: | 1D11 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Galectin-10 |
| Antigen mutation: | No |
| Durg Target: | Q05315 |
Sequence information
Antibody
Heavy Chain: C
Mutation: NULL
| >6GLW_C|Chain C, E[auth H]|Fab 1D11 - Heavy chain|Lama glama (9844) QVQLVESGGGLVQPGGSLRLSCAASGFTFDDYAMSWVRQAPGKGLEWVSGISWNGGSTYYAESMKGRFTISRDNAKNTLYLQMNSLKSEDTAVYYCAKDRNLGYRLGYPYDYWGQGTQVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTH |
Light Chain: D
Mutation: NULL
| >6GLW_D|Chain D, F[auth L]|Fab 1D11 - Light chain|Lama glama (9844) QSVLTQPPSVSGSPGETVTISCAGTSSDVGYGNYVSWYQQLPGMAPRLLIYEVNKRASGITDRFSGSKSGNTASLTISGLQSEDEGDYYCASYRSSNNAVFGGGTHLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS |
Antigen
Chain: B
Mutation: NULL
| >6GLW_B|Chain A, B|Galectin-10|Homo sapiens (9606) MASTTHHHHHHDTDIPTTGGGSRPDDDDKENLYFQGHMSLLPVPYTEAASLSTGSTVTIKGRPLACFLNEPYLQVDFHTEMKEESDIVFHFQVCFGRRVVMNSREYGAWKQQVESKNMPFQDGQEFELSISVLPDKYQVMVNGQSSYTFDHRIKPEAVKMVQVWRDISLTKFNVSYLKR |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| C: ASP30 ASP31 TRP53 ASN54 TYR59 ASN101 LEU102 GLY103 TYR104 ARG105 LEU106 TYR108 D: TYR31 TYR34 LYS55 TYR93 SER95 SER96 ASN97 B: THR42 LYS45 ASP49 GLU68 TYR69 GLY70 ALA71 LYS73 PRO97 HIS114 ARG115 ILE116 LYS117 PRO118 GLU119 ALA120 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
