Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 2245 |
| PDBID: | 6GKU |
| Chains: | HL_A |
| Organism: | Homo sapiens, Lama glama |
| Method: | XRD |
| Resolution (Å): | 1.91 |
| Reference: | 10.1126/science.aaw4295 |
| Antibody | |
| Antibody: | 6F5 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Galectin-10 |
| Antigen mutation: | No |
| Durg Target: | Q05315 |
Sequence information
Antibody
Heavy Chain: H
Mutation: NULL
| >6GKU_H|Chain B[auth H]|Fab 6F5 - Heavy Chain|Lama glama (9844) QLQLVESGGGLVQPGGSLRLSCAASGFTFSSYAMSWVRQAPGKGLEWVSAINSGGGSTSYADSVKGRFTISRDNAKNTLYLQMNSLKPEDTAVYYCATPGDRLWYYRYDYWGQGTQVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTH |
Light Chain: L
Mutation: NULL
| >6GKU_L|Chain C[auth L]|Fab 6F5 - Light chain|Lama glama (9844) QAGLTQPPSVSGTLGKAVTISCAGTSSDIGYGNYVSWYQQLPGTAPKLLIYKVSRRASGVPDRFSGSKSGNTASLSISGLQSEDEADYYCASYRYRNNVVFGGGTHLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS |
Antigen
Chain: A
Mutation: NULL
| >6GKU_A|Chain A|Galectin-10|Homo sapiens (9606) MASTTHHHHHHDTDIPTTGGGSRPDDDDKENLYFQGGHMSLLPVPYTEAASLSTGSTVTIKGRPLACFLNEPYLQVDFHTEMKEESDIVFHFQVCFGRRVVMNSREYGAWKQQVESKNMPFQDGQEFELSISVLPDKYQVMVNGQSSYTFDHRIKPEAVKMVQVWRDISLTKFNVSYLKR |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| H: LEU2 GLY26 PHE27 SER31 TYR32 THR98 PRO99 ARG102 LEU103 TRP104 TYR105 ARG107 ASP109 TYR110 L: ASN33 TYR34 TYR51 LYS52 ARG55 SER58 GLY59 A: THR42 GLU43 ASP49 GLU68 TYR69 ALA71 LYS73 GLN74 ASP98 ASP113 HIS114 ARG115 ILE116 LYS117 GLU119 ALA120 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
