Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 2220 |
| PDBID: | 6G8R |
| Chains: | A_B |
| Organism: | Homo sapiens |
| Method: | XRD |
| Resolution (Å): | 2.74 |
| Reference: | Not available or To be published |
| Antibody | |
| Antibody: | 6G8R scFv |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Nuclear body protein SP140 |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Chain: A
Mutation: NULL
| >6G8R_A|Chain A|single-chain variable fragment|Homo sapiens (9606) EVQLLESGGGLVQPGGSLRLSCAASGFTFYGSGMGWVRQAPGKGLEWVSSIYSGSGSTYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCARTSIYYYYMDYWGQGTLVTVSSGGGGSGGGGSGGGGSDIQMTQSPSSLSASVGDRVTITCRASQSISSYLNWYQQKPGKAPKLLIYAASSLQSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQSSSLFTFGQGTKLEIKRTAENLYFQS |
Antigen
Chain: B
Mutation: NULL
| >6G8R_B|Chain B|Nuclear body protein SP140|Homo sapiens (9606) SMRNLDECEVCRDGGELFCCDTCSRVFHEDCHIPPVEAERTPWNCIFCRMKESPGSQQCCQESEVLERQMCPEEQLKCEFLLLKVYCCSESSFFAKIPYYYYIREACQGLKEPMWLDKIKKRLNEHGYPQVEGFVQDMRLIFQNHRASYKYKDFGQMGFRLEAEFEKNFKEVFAIQESSKGGYGLNDIFEAQKIEWHE |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| A: TYR30 GLY31 SER32 TYR52 SER53 GLY54 SER57 TYR59 ARG98 SER100 ILE101 TYR102 TYR103 TYR104 TYR105 SER164 SER165 TYR166 TYR183 ALA184 ALA185 SER186 SER187 SER225 SER226 SER227 LEU228 B: ARG688 ASP706 THR707 GLU722 GLU724 ARG725 THR726 PRO727 ASN729 CYS733 ARG734 MET735 GLU737 SER738 PRO739 CYS756 PRO757 GLU758 LEU761 LYS762 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
