Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 2206 |
| PDBID: | 6FLC |
| Chains: | HL_G |
| Organism: | Mus musculus, dengue virus type 2 |
| Method: | XRD |
| Resolution (Å): | 2.00 |
| Reference: | 10.1038/s41590-018-0227-7 |
| Antibody | |
| Antibody: | 2C8 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Domain III of Dengue virus 2 |
| Antigen mutation: | No |
| Durg Target: | P27914; P12823; |
Sequence information
Antibody
Heavy Chain: H
Mutation: NULL
| >6FLC_H|Chain B, D[auth H]|Heavy chain of 2C8 Fab|Mus musculus (10090) EVKLVESGGGLVQPGGSLSLSCAASGFTFTDYYMTWVRQPPGKALEWLALIRNKASGYTTEYSASVKGRFTISRDNSQSILYLQMNALRAEDSATYYCTRAKWDGHYFDYWGQGTTLTVSSAKTTAPSVYPLAPVCGDTTGSSVTLGCLVKGYFPEPVTLTWNSGSLSSGVHTFPAVLQSDLYTLSSSVTVTSSTWPSQSITCNVAHPASSTKVDKKIEPRGPTIKPCPPC |
Light Chain: L
Mutation: NULL
| >6FLC_L|Chain A, F[auth L]|Light chain of 2C8 Fab|Mus musculus (10090) DIQMTQSPASLSVSVGETVTITCRATKNIYNNLAWYQQKQGRSPQLLVYAATNLADGVPSRFSGSGSGTQFSLRINSLQSEDFGNYYCQHFWHTPWTFGGGTKLEIKRADAAPTVSIFPPSSEQLTSGGASVVCFLNNFYPKDINVKWKIDGSERQNGVLNSWTDQDSKDSTYSMSSTLTLTKDEYERHNSYTCEATHKTSTSPIVKSFNRNEC |
Antigen
Chain: G
Mutation: NULL
| >6FLC_G|Chain C[auth G], E[auth I]|Domain III of Dengue virus 2|Dengue virus 2 (11060) MSYSMCTGKFKVVKEIAETQHGTIVIRVQYEGDGSPCKIPFEIMDLEKRHVLGRLITVNPIVTEKDSPVNIEAEPPFGDSYIIIGVEPGQLKLNWFKK |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| H: TYR33 ARG52 ALA55 SER56 TRP103 ASP104 HIS106 TYR107 L: TYR30 ASN31 ASN32 TYR49 ALA50 THR52 ASN53 TRP92 HIS93 TRP96 G: MET297 SER298 TYR299 SER300 MET301 THR303 ASP329 GLY330 SER331 PRO332 LYS334 LYS361 ASP362 VAL382 GLU383 PRO384 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
