Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 2203 |
| PDBID: | 6FLA |
| Chains: | HL_I |
| Organism: | Mus musculus, dengue virus type 2 |
| Method: | XRD |
| Resolution (Å): | 2.90 |
| Reference: | 10.1038/s41590-018-0227-7 |
| Antibody | |
| Antibody: | 3H5 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Domain III of Dengue virus 2 |
| Antigen mutation: | No |
| Durg Target: | P27914; P12823; |
Sequence information
Antibody
Heavy Chain: H
Mutation: NULL
| >6FLA_H|Chain A, D[auth H]|Heavy chain|Mus musculus (10090) QVQLQQSGAEVARPGASVKLSCKASGYTFTSYWLQWVKQRPGQGLEWIGAIWPGDDDTRYAQKFQGKATMTADKSSSTAYIQLSNLASEDSAVYYCARKGGFAMDYWGQGTSVTVSSAKTTPPSVYPLAPGSGAQTNSMVTLGCLVKGYFPEPVTVTWNSGSLSSGVHTFPAVLQSDLYTLSSSVTVPSSTWPSETVTCNVAHPASSTKVDKKIEPRDCGKHHHHHH |
Light Chain: L
Mutation: NULL
| >6FLA_L|Chain B, F[auth L]|Light Chain of 3H5|Mus musculus (10090) NIVMTQSPTSLAVSLGQRATISCRASESVDSFGKSFMHFYQQKPGQPPKLLIHLASNLESGVPARFTGRGSRTDFTLTIDPVEADDAATYYCQQNNEVPFTFGSGTKLEVKRADAAPTVSIFPPSSEQLTSGGASVVCFLNNFYPKDINVKWKIDGSERQNGVLNSWTDQDSKDSTYSMSSTLTLTKDEYERHNSYTCEATHKTSTSPIVKSFNRNEC |
Antigen
Chain: I
Mutation: NULL
| >6FLA_I|Chain E[auth I]|Domain III of Dengue virus 2|Dengue virus 2 (11060) MSYSMCTGKFKVVKEIAETQHGTIVIRVQYEGDGSPCKIPFEIMDLEKRHVLGRLITVNPIVTEKDSPVNIEAEPPFGDSYIIIGVEPGQLKLNWFKKGSS |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| H: THR28 THR30 SER31 TYR32 TRP33 GLN35 ALA50 TRP52 GLY54 ASP55 ASP57 ARG59 LYS99 GLY100 GLY101 PHE102 L: SER31 PHE32 GLY33 LYS34 PHE36 ASN95 ASN96 GLU97 VAL98 PHE100 I: SER300 MET301 THR303 GLY304 LYS305 GLU327 GLY328 ASP329 PRO336 PHE337 GLU338 LYS344 LYS361 ILE379 GLY381 VAL382 GLU383 PRO384 GLY385 GLN386 LYS388 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
