Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 2200 |
| PDBID: | 6FG2 |
| Chains: | DE_M |
| Organism: | Homo sapiens |
| Method: | XRD |
| Resolution (Å): | 2.79 |
| Reference: | 10.1038/s41591-019-0568-2 |
| Antibody | |
| Antibody: | anti-idiotype NAA84 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Natalizumab Fab light chain |
| Antigen mutation: | No |
| Durg Target: | P01834 |
Sequence information
Antibody
Heavy Chain: D
Mutation: NULL
| >6FG2_D|Chain A[auth D], C[auth F]|HEAVY CHAIN FAB NAA84|Homo sapiens (9606) EVQLVESGGGLVKPGGSLRLSCAASGFTFSSYSMSWVRQAPGKGLEWVSSISRSTPYIYYADSVKGRFTISRDNAKNSLYLQMNSLRAEDTAVYYCARDLWSPDSNYYDQSAFDIWGQGTMVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTENLYFQ |
Light Chain: E
Mutation: NULL
| >6FG2_E|Chain B[auth E], D[auth G]|LIGHT CHAIN FAB NAA84|Homo sapiens (9606) SSELTQDPAVSVALGQTVRITCQGDSLRSNYASWYQQKPGQAPLLVIYGKNYRPSGIPDRFSGSYSGNTASLTISGAQAEDEADYYCNSRDSSGDHPVVFGGGTNLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS |
Antigen
Chain: M
Mutation: NULL
| >6FG2_M|Chain G[auth L], H[auth M]|LIGHT CHAIN FAB NATALIZUMAB|Homo sapiens (9606) DIQMTQSPSSLSASVGDRVTITCKTSQDINKYMAWYQQTPGKAPRLLIHYTSALQPGIPSRFSGSGSGRDYTFTISSLQPEDIATYYCLQYDNLWTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRG |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| D: SER30 SER31 ARG53 LEU100 TRP101 ASP104 SER105 ASN106 TYR107 M: GLN27 ASN30 TYR32 TYR91 ASP92 ASN93 LEU94 TRP95 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
