Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 2199 |
| PDBID: | 6FG2 |
| Chains: | DE_I |
| Organism: | Homo sapiens |
| Method: | XRD |
| Resolution (Å): | 2.79 |
| Reference: | 10.1038/s41591-019-0568-2 |
| Antibody | |
| Antibody: | anti-idiotype NAA84 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Natalizumab Fab heavy chain |
| Antigen mutation: | No |
| Durg Target: | P01861; P01859; Q6PYX1; P01860; P01857; |
Sequence information
Antibody
Heavy Chain: D
Mutation: NULL
| >6FG2_D|Chain A[auth D], C[auth F]|HEAVY CHAIN FAB NAA84|Homo sapiens (9606) EVQLVESGGGLVKPGGSLRLSCAASGFTFSSYSMSWVRQAPGKGLEWVSSISRSTPYIYYADSVKGRFTISRDNAKNSLYLQMNSLRAEDTAVYYCARDLWSPDSNYYDQSAFDIWGQGTMVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTENLYFQ |
Light Chain: E
Mutation: NULL
| >6FG2_E|Chain B[auth E], D[auth G]|LIGHT CHAIN FAB NAA84|Homo sapiens (9606) SSELTQDPAVSVALGQTVRITCQGDSLRSNYASWYQQKPGQAPLLVIYGKNYRPSGIPDRFSGSYSGNTASLTISGAQAEDEADYYCNSRDSSGDHPVVFGGGTNLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS |
Antigen
Chain: I
Mutation: NULL
| >6FG2_I|Chain E[auth H], F[auth I]|HEAVY CHAIN FAB NATALIZUMAB|Homo sapiens (9606) QVQLVQSGAEVKKPGASVKVSCKASGFNIKDTYIHWVRQAPGQRLEWMGRIDPANGYTKYDPKFQGRVTITADTSASTAYMELSSLRSEDEAVYYCAREGYYGNYGVYAMDYWGQGTLVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGPPENLYFQ |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| D: LEU100 TRP101 ASP104 SER105 ASN106 TYR107 ASP109 GLN110 E: ARG27 SER28 ASN29 TYR30 TYR47 LYS49 TYR51 TYR64 SER91 SER92 I: LYS30 ASP31 THR32 TYR33 ARG50 ASP52 ALA54 ASN55 TYR57 LYS59 GLU99 TYR101 GLY106 VAL107 TYR108 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
