Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 2197 |
| PDBID: | 6FG1 |
| Chains: | AD_H |
| Organism: | Homo sapiens |
| Method: | XRD |
| Resolution (Å): | 2.03 |
| Reference: | 10.1038/s41591-019-0568-2 |
| Antibody | |
| Antibody: | anti-idiotype NAA32 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Natalizumab Fab heavy chain |
| Antigen mutation: | No |
| Durg Target: | P01861; P01859; Q6PYX1; P01860; P01857; |
Sequence information
Antibody
Heavy Chain: A
Mutation: NULL
| >6FG1_A|Chain A|HEAVY CHAIN OF FAB NAA32|Homo sapiens (9606) QVHLVQSGAEVKKPGASVKVSCKASGYTFTSYTMHWVRQAPGQRLEWMGWINAGHGTTKYSQKFQGRVTITRDTSASTAYMELSSLRSEDTAVYYCARPTSEGVAGPSRYYWYFDLWGRGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTENLYFQ |
Light Chain: D
Mutation: NULL
| >6FG1_D|Chain B[auth D]|LIGHT CHAIN OF FAB NAA32|Homo sapiens (9606) EIVMTQSPATLSVSPGERATLSCRASQSVSSNLAWYQQKPGQAPRLLIYGASTRATGIPARFSGSGSGTEFTLTISSLQSEDFAVYYCQQYNNWPPLTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHEGLSSPVTKSFNRGEC |
Antigen
Chain: H
Mutation: NULL
| >6FG1_H|Chain C[auth H]|HEAVY CHAIN OF FAB NATALIZUMAB|Homo sapiens (9606) QVQLVQSGAEVKKPGASVKVSCKASGFNIKDTYIHWVRQAPGQRLEWMGRIDPANGYTKYDPKFQGRVTITADTSASTAYMELSSLRSEDEAVYYCAREGYYGNYGVYAMDYWGQGTLVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGPPENLYFQ |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| A: ASN52 HIS55 THR57 GLY103 VAL104 ALA105 GLY106 PRO107 SER108 ARG109 TYR110 D: ILE2 GLN27 SER28 SER30 ASN32 ASN92 ASN93 TRP94 PRO95 H: LYS30 ASP31 THR32 TYR33 ARG50 ASP52 ALA54 ASN55 TYR57 LYS59 TYR101 GLY103 ASN104 TYR105 GLY106 VAL107 TYR108 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
