Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 2195 |
| PDBID: | 6F2W |
| Chains: | B_A |
| Organism: | Carnobacterium sp. AT7, Lama glama |
| Method: | XRD |
| Resolution (Å): | 3.40 |
| Reference: | 10.1038/s41467-019-09837-z |
| Antibody | |
| Antibody: | 74 Nanobody |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Putative amino acid/polyamine transport protein |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Chain: B
Mutation: NULL
| >6F2W_B|Chain B|Nanobody 74|Lama glama (9844) QVQLVESGGGVVQAGGSLRLSCAASGRTFSSRAMGWFRQAPGEGREFVATISWSGSYTEYADSVKGRVTISRDNAKNTVYLQMNSLKPGDTAVYHCAAKNGGAASNYPNDYVYWGQGTQVTVSSHHHHHHEPEA |
Antigen
Chain: A
Mutation: NULL
| >6F2W_A|Chain A|Putative amino acid/polyamine transport protein|Carnobacterium sp. AT7 (333990) MKEVSGITALTVVVGTVIGAGIFFKPTAVYGAAGAPGLGLLAWFVAGIITIAGGLTVAEIGTIYPQTGGMMIYLEKVYGRWLGFLVGWAQMVIYYPANIAALAIIFATQFVNLFALSDSTIVPTAILTSIFLMGVNFLGTKYSGWIQTLATILKLIPLVVIIVAGLLYPGGGVIRLVPFSVETHPVLTSFGSALIATLFAYDGWINVGTLAGEMKNPGKMLPKVIIGGLSIVMAVYLLTNIAYLFVLDSSQLAGTDTPAALVASHLFEGIGSKLVTIGILISVFGGINGYIISGLRVPYALATQKMLPFSDWFARINPKTNLPINGGLVMLGIAIVMILTGQFNQLTDLIVFVIWFFITLTFIAVIILRKTQPDIERPYRVPFYPVIPLIAIIGGLYIIFNTLIVQPKNAFIGILLTLIGIPIYFYCKKKYGSPEGGGLEVLFQ |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| B: SER31 GLN39 GLY42 GLU43 GLY44 ARG45 GLU46 PHE47 SER52 TRP53 SER56 TYR57 THR58 GLU59 TYR60 ALA61 ASP62 LYS65 LYS99 ASN100 GLY101 GLY102 ALA103 ALA104 SER105 ASN106 TYR107 PRO108 ASN109 ASP110 A: ILE63 TYR64 PRO65 GLN66 THR67 GLY68 ILE72 LYS76 ARG80 THR140 GLY212 GLU213 MET214 LYS215 ILE292 LEU295 ARG296 TYR299 ALA300 THR303 GLN304 LYS305 ALA314 ARG315 ILE316 PRO318 THR320 ASN321 LEU322 PRO323 GLU376 TYR431 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
