Details

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Entry information

Complex
AACDB_ID: 2179
PDBID: 6EHG
Chains: C_B
Organism: Homo sapiens, Lama glama
Method: XRD
Resolution (Å): 2.65
Reference: 10.1074/jbc.RA117.001179
Antibody
Antibody: hC3Nb1 Nanobody
Antibody mutation: No
INN (Clinical Trial):
Antigen
Antigen: Complement C3
Antigen mutation: No
Durg Target: P01024

Sequence information

Antibody

Chain: C
Mutation: NULL

>6EHG_C|Chain C|hC3Nb1|Lama glama (9844)
MQVQLVETGGGLVQAGGSLRLSCAASGSIFSLNAMGWFRQAPGKEREFVATINRSGGRTYYADSVKGRFTISRDNGKNMVYLQMHSLKPEDTAIYYCAAGTGWSPQTDNEYNYWGQGTQVTVSSHHHHHH

Antigen

Chain: B
Mutation: NULL

>6EHG_B|Chain B|Complement C3|Homo sapiens (9606)
SNLDEDIIAEENIVSRSEFPESWLWNVEDLKEPPKNGISTKLMNIFLKDSITTWEILAVSMSDKKGICVADPFEVTVMQDFFIDLRLPYSVVRNEQVEIRAVLYNYRQNQELKVRVELLHNPAFCSLATTKRRHQQTVTIPPKSSLSVPYVIVPLKTGLQEVEVKAAVYHHFISDGVRKSLKVVPEGIRMNKTVAVRTLDPERLGREGVQKEDIPPADLSDQVPDTESETRILLQGTPVAQMTEDAVDAERLKHLIVTPSGCGEENMIGMTPTVIAVHYLDETEQWEKFGLEKRQGALELIKKGYTQQLAFRQPSSAFAAFVKRAPSTWLTAYVVKVFSLAVNLIAIDSQVLCGAVKWLILEKQKPDGVFQEDAPVIHQEMIGGLRNNNEKDMALTAFVLISLQEAKDICEEQVNSLPGSITKAGDFLEANYMNLQRSYTVAIAGYALAQMGRLKGPLLNKFLTTAKDKNRWEDPGKQLYNVEATSYALLALLQLKDFDFVPPVVRWLNEQRYYGGGYGSTQATFMVFQALAQYQKDAPDHQELNLDVSLQLPSRSSKITHRIHWESASLLRSEETKENEGFTVTAEGKGQGTLSVVTMYHAKAKDQLTCNKFDLKVTIKPAPETEKRPQDNKNTMILEICTRYRGDQDATMSILDISMMTGFAPDTDDLKQLANGVDRYISKYELDKAFSDRNTLIIYLDKVSHSEDDCLAFKVHQYFNVELIQPGAVKVYAYYNLEESCTRFYHPEKEDGKLNKLCRDELCRCAEENCFIQKSDDKVTLEERLDKACEPGVDYVYKTRLVKVQLSNDFDEYIMAIEQTIKSGSDEVQVGQQRTFISPIKCREALKLEEKKHYLMWGLSSDFWGEKPNLSYIIGKDTWVEHWPEEDECQDEENQKQCQDLGAFTESMVVFGCPN

Interaction

1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.

Interacting residues (ΔSASA based)

Chain residues position delta_SASA : residuesposition

C: ASN32 ALA33 THR50 ILE51 ASN52 ARG53 SER54 GLY56 ARG57 THR58 TYR59 THR100 GLY101 TRP102 SER103 PRO104 GLN105 GLU109

B: ILE756 GLU758 GLU759 ASN760 ILE761 VAL762 ASP828 PHE829 ARG855 GLN858 LEU860 VAL916 HIS918 HIS919 PHE920 ILE921 SER922

2、We defined interacting paratope-epitope residues by a distance cutoff of < 6 Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 6 Å from any atom.

Interacting residues (Atom distance based)

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