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Entry information

Complex
AACDB_ID: 2177
PDBID: 6E63
Chains: HL_P
Organism: Plasmodium falciparum, Homo sapiens
Method: XRD
Resolution (Å): 2.60
Reference: 10.1038/s41467-018-06742-9
Antibody
Antibody: TB31F Fab
Antibody mutation: No
INN (Clinical Trial):
Antigen
Antigen: malaria transmission-blocking antigen Pfs48/45 6C
Antigen mutation: No
Durg Target:

Sequence information

Antibody

Heavy Chain: H
Mutation: NULL

>6E63_H|Chain B, E[auth H]|TB31F Fab heavy chain|Homo sapiens (9606)
EVQLVQSGGGLVQPGGSLRLSCAASGFTFNNYWMSWVRQAPGKGLEWVSSISNIGGTIYYPDSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCTRDLRMSDYFDYWGQGTMVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSC

Light Chain: L
Mutation: NULL

>6E63_L|Chain C, F[auth L]|TB31F Fab light chain|Homo sapiens (9606)
NFMLTQPHSVSESPGKTVTISCTRSTGNIGSNYVSWYQQRPGSSPTTVIYRDDQRPSGVPDRFSGSIDRSSNSASLTISGLKTEDEADYYCHSYSTGMYIFGGGTKLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTEC

Antigen

Chain: P
Mutation: NULL

>6E63_P|Chain A, D[auth P]|Pf48/45|Plasmodium falciparum (5833)
EKKVIHGCNFSSNVSSKHTFTDSLDISLVDDSAHISCNVHLSEPKYNHLVGLNCPGDIIPDCFFQVYQPESEELEPSNIVYLDSQINIGDIEYYEDAEGDDKIKLFGIVGSIPKTTSFTCICKKDKKSAYMTVTIDSA

Interaction

1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.

Interacting residues (ΔSASA based)

Chain residues position delta_SASA : residuesposition

H: ASN30 ASN31 TRP33 ASN52 ILE53 GLY55 THR56 TYR58 ARG97 MET98

L: GLY29 SER30 ASN31 TYR32 ARG50 ASP51 ARG66 TYR91 SER92 THR93

P: ASP321 SER322 PRO345 GLY346 ASP347 ILE348 ILE349 PRO350 ASP351 PHE354 GLN355 TYR357 GLU365 ILE369 TYR371 GLU385 ASP390 LYS392 LYS394 ILE411 LYS413 LYS414 ASP415 LYS416 SER418

2、We defined interacting paratope-epitope residues by a distance cutoff of < 6 Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 6 Å from any atom.

Interacting residues (Atom distance based)

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