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Entry information

Complex
AACDB_ID: 2174
PDBID: 6E56
Chains: GI_D
Organism: Influenza A virus (A/Aichi/2/1968(H3N2)), Homo sapiens
Method: XRD
Resolution (Å): 2.00
Reference: 10.1016/j.cell.2019.03.048
Antibody
Antibody: H2214 Fab
Antibody mutation: No
INN (Clinical Trial):
Antigen
Antigen: Influenza A virus H3N2 hemagglutinin
Antigen mutation: No
Durg Target: P03437

Sequence information

Antibody

Heavy Chain: G
Mutation: NULL

>6E56_G|Chain C[auth G], D[auth H]|antibody H2214 heavy chain|Homo sapiens (9606)
EVQLLESGGGLVQPGGSLRLSCAASGFTFNHYAMTWVRQAPGKGLEWVASSSGSGRSTYYTDSVKGRFSVSRDNSKNTLYLQMNSLRAEDTAVYYCAKSSNYYGSGSYSPDDYYHMDVWGQGTTVTVSGASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKGSSLEVLFQGPLGHHHHHH

Light Chain: I
Mutation: NULL

>6E56_I|Chain E[auth I], F[auth J]|antibody H2214 light chain, K1642|Homo sapiens (9606)
EIVMTQSPDTLSVSPGERATLSCRASESISSNLAWYQQKPGQVPRLLIYGASTRATGVPARFTGSGSGTEFTLTISSLQSEDFAVYYCQQYNNRLPYTFGQGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC

Antigen

Chain: D
Mutation: NULL

>6E56_D|Chain A, B[auth D]|Hemagglutinin|Influenza A virus (387139)
TNATELVQSSSTGKICNNPHRILDGIDCTLIDALLGDPHCDVFQNETWDLFVERSKAFSNCYPYDVPDYASLRSLVASSGTLEFITEGFTWTGVTQNGGSNACKRGPGSGFFSRLNWLTKSGSTYPVLNVTMPNNDNFDKLYIWGIHHPSTDQEQTSLYVQASGRVTVSTRRSQQTIIPNIGSRPWVRGLSSRISIYWTIVKPGDVLVINSNGNLIAPRGYFKMRTGKSSIMRSDAPIDTCISECITPNGSIPNDKPFQNVNKITYGACPKYVKQNTLKLATGGLEVLFQ

Interaction

1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.

Interacting residues (ΔSASA based)

Chain residues position delta_SASA : residuesposition

G: THR28 ASN30 HIS31 SER54 ARG56 SER57 TYR59 ASN74 SER75 TYR103 GLY106 SER107 TYR108 SER109 PRO110 ASP111 ASP112 TYR113 TYR114

I: ASN92 ASN93 ARG94 PRO96

D: THR65 SER91 ALA93 PHE94 SER95 ASN96 PRO99 TYR100 ASP101 VAL102 PRO103 ASP104 TYR105 ALA106 HIS184 SER219 ARG220 PRO221 TRP222 VAL223 ARG224 SER227 ARG229 SER231 TYR233 ARG269 ASP271

2、We defined interacting paratope-epitope residues by a distance cutoff of < 6 Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 6 Å from any atom.

Interacting residues (Atom distance based)

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