Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 2174 |
| PDBID: | 6E56 |
| Chains: | GI_D |
| Organism: | Influenza A virus (A/Aichi/2/1968(H3N2)), Homo sapiens |
| Method: | XRD |
| Resolution (Å): | 2.00 |
| Reference: | 10.1016/j.cell.2019.03.048 |
| Antibody | |
| Antibody: | H2214 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Influenza A virus H3N2 hemagglutinin |
| Antigen mutation: | No |
| Durg Target: | P03437 |
Sequence information
Antibody
Heavy Chain: G
Mutation: NULL
| >6E56_G|Chain C[auth G], D[auth H]|antibody H2214 heavy chain|Homo sapiens (9606) EVQLLESGGGLVQPGGSLRLSCAASGFTFNHYAMTWVRQAPGKGLEWVASSSGSGRSTYYTDSVKGRFSVSRDNSKNTLYLQMNSLRAEDTAVYYCAKSSNYYGSGSYSPDDYYHMDVWGQGTTVTVSGASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKGSSLEVLFQGPLGHHHHHH |
Light Chain: I
Mutation: NULL
| >6E56_I|Chain E[auth I], F[auth J]|antibody H2214 light chain, K1642|Homo sapiens (9606) EIVMTQSPDTLSVSPGERATLSCRASESISSNLAWYQQKPGQVPRLLIYGASTRATGVPARFTGSGSGTEFTLTISSLQSEDFAVYYCQQYNNRLPYTFGQGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC |
Antigen
Chain: D
Mutation: NULL
| >6E56_D|Chain A, B[auth D]|Hemagglutinin|Influenza A virus (387139) TNATELVQSSSTGKICNNPHRILDGIDCTLIDALLGDPHCDVFQNETWDLFVERSKAFSNCYPYDVPDYASLRSLVASSGTLEFITEGFTWTGVTQNGGSNACKRGPGSGFFSRLNWLTKSGSTYPVLNVTMPNNDNFDKLYIWGIHHPSTDQEQTSLYVQASGRVTVSTRRSQQTIIPNIGSRPWVRGLSSRISIYWTIVKPGDVLVINSNGNLIAPRGYFKMRTGKSSIMRSDAPIDTCISECITPNGSIPNDKPFQNVNKITYGACPKYVKQNTLKLATGGLEVLFQ |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| Chain residues position delta_SASA
: residuesposition G: THR28 ASN30 HIS31 SER54 ARG56 SER57 TYR59 ASN74 SER75 TYR103 GLY106 SER107 TYR108 SER109 PRO110 ASP111 ASP112 TYR113 TYR114 I: ASN92 ASN93 ARG94 PRO96 D: THR65 SER91 ALA93 PHE94 SER95 ASN96 PRO99 TYR100 ASP101 VAL102 PRO103 ASP104 TYR105 ALA106 HIS184 SER219 ARG220 PRO221 TRP222 VAL223 ARG224 SER227 ARG229 SER231 TYR233 ARG269 ASP271 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 6 Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 6 Å from any atom.
Interacting residues (Atom distance based)
