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Entry information

Complex
AACDB_ID: 2172
PDBID: 6E4X
Chains: ZY_B
Organism: Influenza A virus (A/Texas/50/2012(H3N2)), Homo sapiens
Method: XRD
Resolution (Å): 2.25
Reference: 10.1016/j.cell.2019.03.048
Antibody
Antibody: S5V2-29 Fab
Antibody mutation: No
INN (Clinical Trial):
Antigen
Antigen: Influenza A virus H3N2 hemagglutinin
Antigen mutation: No
Durg Target:

Sequence information

Antibody

Heavy Chain: Z
Mutation: NULL

>6E4X_Z|Chain C[auth Z]|S5V2-29 heavy chain|Homo sapiens (9606)
QVQLQESGPGLVKPSETLSLTCTVSGGSVSSNIYYWSWIRQTPGKGLEWLGYFYHSGSSNYNPSLKSRVTISGDMSKNQFSLKLKSVTAADTAIYYCARGGVENLMLVAVIQEMWYFDLWGRGTLVTVSGASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKHHHHHH

Light Chain: Y
Mutation: NULL

>6E4X_Y|Chain B[auth Y]|S5V2-29 light chain|Homo sapiens (9606)
DIQMTQTPSSLSASVGDRVTITCRASQSIGASLNWYQQKPGEAPKFLIYAASNLQSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQQGTFGQGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC

Antigen

Chain: B
Mutation: NULL

>6E4X_B|Chain A[auth B]|Hemagglutinin|Influenza A virus (A/Texas/50/2012(H3N2)) (1321009)
TNATELVQNSSIGEICDSPHQILDGENCTLIDALLGDPQCDGFQNKKWDLFVERSKAYSNCYPYDVPDYASLRSLVASSGTLEFNNESFNWNGVTQNGTSSACIRRSNNSFFSRLNWLTHLNFKYPALNVTMPNNEQFDKLYIWGVHHPVTDKDQIFLYAQPSGRITVSTKRSQQAVIPNIGFRPRIRNIPSRISIYWTIVKPGDILLINSTGNLIAPRGYFKIRSGKSSIMRSDAPIGKCKSECITPNGSIPNDKPFQNVNRITYGACPRYVKQSTLKLATGGALEVLFQ

Interaction

1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.

Interacting residues (ΔSASA based)

Chain residues position delta_SASA : residuesposition

Y: PHE46 TYR49 ALA50 ASN53 LEU54 GLN55 SER56 GLY57

Z: SER31 ASN32 ILE33 TYR34 ARG99 GLU103 ASN104 LEU105 MET106 LEU107 VAL108 ALA109 VAL110 ILE111 TYR116 ASP118

B: THR65 GLU89 ARG90 SER91 ALA93 TYR94 SER95 PRO99 TYR100 ASP101 VAL102 TYR105 ASN216 ILE217 GLY218 PHE219 ARG220 PRO221 ARG222 ILE223 ARG224 ASN225 ARG229 ARG269

2、We defined interacting paratope-epitope residues by a distance cutoff of < 6 Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 6 Å from any atom.

Interacting residues (Atom distance based)

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