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Entry information

Complex
AACDB_ID: 2171
PDBID: 6E1K
Chains: FE_A
Organism: Arabidopsis thaliana, Homo sapiens
Method: EM
Resolution (Å): 3.30
Reference: 10.1073/pnas.1805651115
Antibody
Antibody: cat06 Fab
Antibody mutation: No
INN (Clinical Trial):
Antigen
Antigen: Two pore calcium channel protein 1
Antigen mutation: No
Durg Target:

Sequence information

Antibody

Heavy Chain: F
Mutation: NULL

>6E1K_F|Chain D, F|cat06 heavy chain|Homo sapiens (9606)
EVQLVESGGGLVQPGGSLRLSCAASGFNVYSYSIHWVRQAPGKGLEWVASISSYYSSTSYADSVKGRFTISADTSKNTAYLQMNSLRAEDTAVYYCARSYWYWRTSTLGGIDYWGQGTLVTVFNQIKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHT

Light Chain: E
Mutation: NULL

>6E1K_E|Chain C, E|cat06 light chain|Homo sapiens (9606)
DIQMTQSPSSLSASVGDRVTITCRASQSVSSAVAWYQQKPGKAPKLLIYSASSLYSGVPSRFSGSRSGTDFTLTISSLQPEDFATYYCQQSSSSLITFGQGTKVEIKRTVAAPSVFIFPPSDSQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC

Antigen

Chain: A
Mutation: NULL

>6E1K_A|Chain A, B|Two pore calcium channel protein 1|Arabidopsis thaliana (3702)
MGGGGTDRVRRSEAITHGTPFQKAAALVDLAEDGIGLPVEILDQSSFGESARYYFIFTRLDLIWSLNYFALLFLNFFEQPLWCEKNPKPSCKDRDYYYLGELPYLTNAESIIYEVITLAILLVHTFFPISYEGSRIFWTSRLNLVKVACVVILFVDVLVDFLYLSPLAFDFLPFRIAPYVRVIIFILSIRELRDTLVLLSGMLGTYLNILALWMLFLLFASWIAFVMFENTQQGLTVFTSYGATLYQMFILFTTSNNPDVWIPAYKSSRWSSVFFVLYVLIGVYFVTNLILAVVYDSFKEQLAKQVSGMDQMKRRMLEKAFGLIDSDKNGEIDKNQCIKLFEQLTNYRTLPKISKEEFGLIFDELDDTRDFKINKDEFADLCQAIALRFQKEEVPSLFEHFPQIYHSALSQQLRAFVRSPNFGYAISFILIINFIAVVVETTLNIEESSAQKPWQVAEFVFGWIYVLEMALKIYTYGFENYWREGANRFDFLVTWVIVIGETATFITPDENTFFSNGQWIRYLLLARMLRLIRLLMNVQRYRAFIATFITLIPSLMPYLGTIFCVLCIYCSIGVQVFGGLVNAGNKKLFETELAEDDYLLFNFNDYPNGMVTLFNLLVMGNWQVWMESYKDLTGTWWSITYFVSFYVITILLLLNLVVAFVLEAFFTELDLEEEEKCQGQDSQEKRNRRRSAGSKSRSQRVDTLLHHMLGDELSKPECSTSDTLVPR

Interaction

1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.

Interacting residues (ΔSASA based)

Chain residues position delta_SASA : residuesposition

E: SER28 VAL29 SER30 SER31 TYR49 THR69 SER93

F: PHE27 VAL29 TYR30 SER31 TYR32 SER53 TYR54 TYR55 SER56 SER57 TYR100 TRP101 TRP103 ARG104 THR107 LEU108 ASP112

A: SER56 PHE57 GLY58 ARG145 ILE146 GLN321 ARG324 ARG325 LEU327 GLU328 LYS329 PHE331 GLY332 ASP335 LYS338 ASN339 GLY340 GLU341 LEU375 ASP377 ILE383 ASN384 LYS385 ASP386 GLU387 ALA389

2、We defined interacting paratope-epitope residues by a distance cutoff of < 6 Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 6 Å from any atom.

Interacting residues (Atom distance based)

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