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Entry information

Complex
AACDB_ID: 2162
PDBID: 6DO1
Chains: C_A
Organism: Homo sapiens, Escherichia coli, synthetic construct
Method: XRD
Resolution (Å): 2.90
Reference: 10.1016/j.cell.2018.12.006
Antibody
Antibody: Nb.AT110i1 Nanobody
Antibody mutation: No
INN (Clinical Trial):
Antigen
Antigen: angiotensin II (AngII) type 1 receptor (AT1R)
Antigen mutation: Yes
Durg Target: P30556; P30556;

Sequence information

Antibody

Chain: C
Mutation: NULL

>6DO1_C|Chain C, D, E, F|Nanobody Nb.AT110i1|synthetic construct (32630)
QVQLQESGGGLVQAGGSLRLSCAASGNIFDVDIMGWYRQAPGKERELVASITDGGSTDYADSVKGRFTISRDNAKNTVYLQMNSLKPEDTAVYYCAAVAYPDIPTYFDYDSDNFYWGQGTQVTVSS

Antigen

Chain: A
Mutation: M239W

>6DO1_A|Chain A, B|Type-1 angiotensin II receptor,Soluble cytochrome b562 BRIL fusion protein|Homo sapiens (9606)
DYKDDDDKILNSSTEDGIKRIQDDCPKAGRHNYIFVMIPTLYSIIFVVGIFGNSLVVIVIYFYMKLKTVASVFLLNLALADLCFLLTLPLWAVYTAMEYRWPFGNYLCKIASASVSFNLYASVFLLTCLSIDRYLAIVHPMKSRLRRTMLVAKVTCIIIWLLAGLASLPAIIHRNVFFIENTNITVCAFHYESQNSTLPIGLGLTKNILGFLFPFLIILTSYTLIWKALKKAYDLEDNWETLNDNLKVIEKADNAAQVKDALTKMRAAALDAQKATPPKLEDKSPDSPEMKDFRHGFDILVGQIDDALKLANEGKVKEAQAAAEQLKTTRNAEIQKNKPRNDDIFKIIMAIVLFFFFSWIPHQIFTFLDVLIQLGIIRDCRIADIVDTAMPITICIAYFNNCLNPLFYGFLGKKFKRYFLQLLKY

Interaction

1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.

Interacting residues (ΔSASA based)

Chain residues position delta_SASA : residuesposition

C: GLN1 ILE33 MET34 GLY35 TYR37 ARG45 GLU46 LEU47 SER50 ASP58 ALA96 VAL98 TYR100 PRO101 ASP102 ILE103 PRO104 THR105 TYR106 PHE107 ASP108 TYR109 ASP110 SER111 ASP112 PHE114 TRP116

A: ILE53 MET57 LYS60 THR61 VAL62 ALA63 SER64 LEU67 LEU122 ARG126 ALA129 ILE130 PRO133 MET134 LYS135 ARG137 LEU138 ARG140 TYR215 LEU222 ARG333 ASN334 ASP336 ILE337 ILE340 ILE344 TYR401 GLY402 LEU404 GLY405 LYS406 LYS407 PHE408 TYR411

2、We defined interacting paratope-epitope residues by a distance cutoff of < 6 Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 6 Å from any atom.

Interacting residues (Atom distance based)

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