Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 2160 |
| PDBID: | 6DKJ |
| Chains: | AB_D |
| Organism: | Homo sapiens |
| Method: | XRD |
| Resolution (Å): | 1.95 |
| Reference: | 10.1126/scitranslmed.aat3392 |
| Antibody | |
| Antibody: | hGIPR-Ab Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Gastric inhibitory polypeptide receptor |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: A
Mutation: NULL
| >6DKJ_A|Chain A, D[auth H]|Fab heavy chain|Homo sapiens (9606) QVQLVESGGGVVQPGRSLRLSCAASGFTFSNYGMHWVRQAPGEGLEWVAAIWFDASDKYYADAVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCARDQAIFGVVPDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSC |
Light Chain: B
Mutation: NULL
| >6DKJ_B|Chain B, E[auth L]|Fab light chain|Homo sapiens (9606) EIVMTQSPATLSVSPGERATLSCRASQSVSSNLAWYQQKPGQAPRLLIYGAATRATGIPARVSGSGSGTEFTLTISSLQSEDFAVYYCQQYNNWPLTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC |
Antigen
Chain: D
Mutation: NULL
| >6DKJ_D|Chain C, F[auth D]|Gastric inhibitory polypeptide receptor|Homo sapiens (9606) RAETGSKGQTAGELYQRWERYRRECQETLAAAEPPSGLACNGSFDMYVCWDYAAPNATARASCPWYLPWHHHVAAGFVLRQCGSDGQWGLWRDHTQCENPEKNEAFLDQRLILERLQ |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| A: THR28 SER30 ASN31 TYR32 TRP52 PHE53 ASP54 ALA55 SER56 ASP57 LYS58 TYR60 LYS65 GLY66 ARG67 PHE68 THR69 SER71 ASN84 GLN100 ALA101 ILE102 PHE103 VAL105 VAL106 B: SER30 SER31 ASN32 TYR49 TYR91 ASN92 ASN93 TRP94 D: GLN30 THR31 ALA32 GLY33 LEU35 TYR36 GLN37 TRP39 ASP66 MET67 TYR68 TYR87 LEU88 PRO89 TRP90 ARG101 LEU111 ARG113 HIS115 GLU119 ASN120 LYS123 GLU125 LEU128 ASP129 ARG131 LEU132 ILE133 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
