Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 2154 |
| PDBID: | 6DDR |
| Chains: | BA_C |
| Organism: | Mus musculus, Homo sapiens |
| Method: | XRD |
| Resolution (Å): | 1.90 |
| Reference: | 10.1080/19420862.2018.1532767 |
| Antibody | |
| Antibody: | Anti-MICA clone 13A9 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | MHC class I polypeptide-related sequence A |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: B
Mutation: NULL
| >6DDR_B|Chain B|Anti-MICA Fab fragment heavy chain clone 13A9|Mus musculus (10090) QVQLQQSGAELVRPGTSVKVSCKASGYAFTNYLIEWVKQRPGQGLEWIGAINPGSGATNYNEKFKDKARLTADKSSNTAYLQFSSLTSDDSAVYFCARFLGNYFDNWGQGATLTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCD |
Light Chain: A
Mutation: NULL
| >6DDR_A|Chain A|Anti-MICA Fab fragment light chain clone 13A9|Mus musculus (10090) DIQMTQSPASLSASVGETVTITCRASGNIHSYLAWYQQKQGKSPQLLVYYAETLADGVPSRFSGRGSGTQYSLKINSLQPEDFGSYFCQQFWTTPYTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC |
Antigen
Chain: C
Mutation: NULL
| >6DDR_C|Chain C|MHC class I polypeptide-related sequence A|Homo sapiens (9606) TVPPMVNVTRSEASEGNITVTCRASSFYPRNIILTWRQDGVSLSHDTQQWGDVLPDGNGTYQTWVATRICRGEEQRFTCYMEHSGNHSTHPVPS |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| A: HIS30 SER31 TYR32 TYR50 PHE91 TRP92 THR94 TYR96 B: THR30 ASN31 TYR32 LEU33 ALA50 SER54 ALA56 THR57 ASN58 PHE95 LEU96 GLY97 ASN98 C: ILE236 ARG240 ASP242 GLY243 VAL244 GLN278 ARG279 PHE280 THR281 TYR283 GLU285 GLY288 ASN289 HIS290 SER291 THR292 PRO294 VAL295 PRO296 SER297 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
