Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 2151 |
| PDBID: | 6DC5 |
| Chains: | EF_D |
| Organism: | Human respiratory syncytial virus A2, Human immunodeficiency virus 1, Homo sapiens |
| Method: | XRD |
| Resolution (Å): | 3.50 |
| Reference: | 10.1371/journal.ppat.1007944 |
| Antibody | |
| Antibody: | AM22 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | RSV fusion glycoprotein |
| Antigen mutation: | Yes |
| Durg Target: | P03420; P11209; |
Sequence information
Antibody
Heavy Chain: E
Mutation: NULL
| >6DC5_E|Chain D[auth B], F[auth E], H|Fab AM22 heavy chain|Homo sapiens (9606) QVQLVQSGAEVKKPGATVKVSCKISGHTLIKLSIHWVRQAPGKGLEWMGGYEGEVDEIFYAQKFQHRLTVIADTATDTVYMELGRLTSDDTAVYFCGTLGVTVTEAGLGIDDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCD |
Light Chain: F
Mutation: NULL
| >6DC5_F|Chain E[auth C], G[auth F], I|Fab AM22 light chain|Homo sapiens (9606) EIVLTQSPGTLSLSPGERATLSCRASQIVSRNHLAWYQQKPGQAPRLLIFGASSRATGIPVRFSGSGSGTDFTLTINGLAPEDFAVYYCLSSDSSIFTFGPGTKVDFKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC |
Antigen
Chain: D
Mutation: P102A/S155C/S190F/V207L/S290C/I379V/M447V
| >6DC5_D|Chain A, B[auth D], C[auth G]|RSV fusion glycoprotein|Human respiratory syncytial virus A (strain A2) (11259) MELLILKANAITTILTAVTFCFASGQNITEEFYQSTCSAVSKGYLSALRTGWYTSVITIELSNIKENKCNGTDAKVKLIKQELDKYKNAVTELQLLMQSTPATNNRARRELPRFMNYTLNNAKKTNVTLSKKRKRRFLGFLLGVGSAIASGVAVCKVLHLEGEVNKIKSALLSTNKAVVSLSNGVSVLTFKVLDLKNYIDKQLLPILNKQSCSISNIETVIEFQQKNNRLLEITREFSVNAGVTTPVSTYMLTNSELLSLINDMPITNDQKKLMSNNVQIVRQQSYSIMCIIKEEVLAYVVQLPLYGVIDTPCWKLHTSPLCTTNTKEGSNICLTRTDRGWYCDNAGSVSFFPQAETCKVQSNRVFCDTMNSLTLPSEVNLCNVDIFNPKYDCKIMTSKTDVSSSVITSLGAIVSCYGKTKCTASNKNRGIIKTFSNGCDYVSNKGVDTVSVGNTLYYVNKQEGKSLYVKGEPIINFYDPLVFPSDEFDASISQVNEKINQSLAFIRKSDELLSAIGGYIPEAPRDGQAYVRKDGEWVLLSTFLGGLVPRGSHHHHHHSAWSHPQFEK |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| E: VAL2 GLY26 HIS27 LYS31 SER33 GLU53 GLY96 THR98 ASP100 ASP101 TYR102 F: PHE49 SER53 ARG54 ALA55 THR56 GLY57 ILE58 D: LYS68 ASN70 GLY71 THR72 TYR198 LYS201 GLN202 LEU203 PRO205 ILE206 ASN208 LYS209 GLN210 SER211 CYS212 SER213 ILE214 SER215 THR219 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
