Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 2149 |
| PDBID: | 6DC3 |
| Chains: | HL_F |
| Organism: | Homo sapiens, Human respiratory syncytial virus A2, Human immunodeficiency virus 1, unidentified |
| Method: | XRD |
| Resolution (Å): | 3.50 |
| Reference: | 10.1371/journal.ppat.1007944 |
| Antibody | |
| Antibody: | RSD5 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | RSV fusion glycoprotein |
| Antigen mutation: | Yes |
| Durg Target: | P03420; P11209; |
Sequence information
Antibody
Heavy Chain: H
Mutation: NULL
| >6DC3_H|Chain A[auth H]|Fab RSD5-Germline Heavy Chain|Homo sapiens (9606) QVQLVESGGGVVQPGRSLRLSCAASGFAFNNFAMHWVRQAPGKGLEWVAVVSYDGTSPYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCARGLGSGSYSWIGYFYAMDVWGQGTTVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSC |
Light Chain: L
Mutation: NULL
| >6DC3_L|Chain B[auth L]|Fab RSD5-Germline Light Chain|Homo sapiens (9606) QSALTQPASVSGSPGQSITISCTGTSSDVGGYVYVSWYQQHPGKAPKLMIYDVSNRPSGVSNRFSGSKSGNTASLTISGLQAEDEADYYCISYTDRNTVVFGGGTKLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS |
Antigen
Chain: F
Mutation: P102A/S155C/S190F/V207L/S290C/I379V/M447V
| >6DC3_F|Chain C[auth F]|RSV fusion glycoprotein|Human respiratory syncytial virus A (strain A2) (11259) MELLILKANAITTILTAVTFCFASGQNITEEFYQSTCSAVSKGYLSALRTGWYTSVITIELSNIKENKCNGTDAKVKLIKQELDKYKNAVTELQLLMQSTPATNNRARRELPRFMNYTLNNAKKTNVTLSKKRKRRFLGFLLGVGSAIASGVAVCKVLHLEGEVNKIKSALLSTNKAVVSLSNGVSVLTFKVLDLKNYIDKQLLPILNKQSCSISNIETVIEFQQKNNRLLEITREFSVNAGVTTPVSTYMLTNSELLSLINDMPITNDQKKLMSNNVQIVRQQSYSIMCIIKEEVLAYVVQLPLYGVIDTPCWKLHTSPLCTTNTKEGSNICLTRTDRGWYCDNAGSVSFFPQAETCKVQSNRVFCDTMNSLTLPSEVNLCNVDIFNPKYDCKIMTSKTDVSSSVITSLGAIVSCYGKTKCTASNKNRGIIKTFSNGCDYVSNKGVDTVSVGNTLYYVNKQEGKSLYVKGEPIINFYDPLVFPSDEFDASISQVNEKINQSLAFIRKSDELLSAIGGYIPEAPRDGQAYVRKDGEWVLLSTFLGGLVPRGSHHHHHHSAWSHPQFEK |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| H: TYR52 ASP53 GLY54 THR55 SER56 PRO57 TYR58 GLY97 SER98 L: GLY29 TYR30 VAL31 TYR32 VAL51 LYS66 TYR91 ASP93 F: GLU60 ASN63 ILE64 LYS65 GLU66 ASN165 LYS168 LEU172 LYS196 ASP200 LYS201 LEU204 PRO205 ILE206 ASN208 LYS209 GLN210 SER211 GLU294 GLU295 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
