Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 2135 |
| PDBID: | 6CXC |
| Chains: | XY_D |
| Organism: | Mus musculus, Human respiratory syncytial virus A2, Human immunodeficiency virus 1 |
| Method: | EM |
| Resolution (Å): | 3.90 |
| Reference: | 10.1371/journal.pone.0210749 |
| Antibody | |
| Antibody: | R4.C6 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | respiratory syncytial virus fusion protein |
| Antigen mutation: | No |
| Durg Target: | P03420; P11209; P13843; |
Sequence information
Antibody
Heavy Chain: X
Mutation: NULL
| >6CXC_X|Chain A[auth G], C[auth I], E[auth X]|R4.C6 Fab Heavy Chain|Mus musculus (10090) MAEVQLQQSGPELVKPGASVKISCKASGYAFSNSWMSWVKQRPGKGLEWIGRLFPADGDITYNGHFKDKAALTADKSSNTAYIQLSSLTSEDSAVYFCARMDNSEVFWGQGTLVTVSA |
Light Chain: Y
Mutation: NULL
| >6CXC_Y|Chain B[auth J], D[auth K], F[auth Y]|R4.C6 Fab Light Chain|Mus musculus (10090) MADILLTQSQKFMSTSVGDRVSITCKASQNVRTGVSWYQRKPGQSPKALIYLASNRHTGVPDRFTGRGSGTDFTLTISEVQSEDLADYFCLQHWTVPYTFGGGTKLEIKRTAAAPSRANSFK |
Antigen
Chain: D
Mutation: NULL
| >6CXC_D|Chain G[auth A], H[auth B], I[auth C], J[auth D], K[auth E], L[auth F]|Fusion glycoprotein F0, Envelope glycoprotein chimera|Human respiratory syncytial virus A (strain A2) (11259) QNITEEFYQSTCSAVSKGYLSALRTGWYTSVITIELSNIKENKCNGTDAKVKLIKQELDKYKNAVTELQLLMQSTPATNNRARRELPRFMNYTLNNAKKTNVTLSKKQKQQFLGFLLGVGSAIASGVAVSKVLHLEGEVNKIKSALLSTNKAVVSLSNGVSVLTSKVLDLKNYIDKQLLPIVNKQSCSISNIETVIEFQQKNNRLLEITREFSVNAGVTTPVSTYMLTNSELLSLINDMPITNDQKKLMSNNVQIVRQQSYSIMSIIKEEVLAYVVQLPLYGVIDTPCWKLHTSPLCTTNTKEGSNICLTRTDRGWYCDNAGSVSFFPQAETCKVQSNRVFCDTMNSLTLPSEVNLCNVDIFNPKYDCKIMTSKTDVSSSVITSLGAIVSCYGKTKCTASNKNRGIIKTFSNGCDYVSNKGVDTVSVGNTLYYVNKQEGKSLYVKGEPIINFYDPLVFPSDEFDASISQVNEKINQSLAFIRKSDELLHNVNAGKSTTNIMGALVPRGSPGSGYIPEAPRDGQAYVRKDGEWVLLSTFLGSSHHHHHH |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| X: ASN29 SER30 TRP31 ARG48 PHE50 ASP53 ASP55 MET97 ASP98 ASN99 Y: ARG144 THR145 TYR163 LEU164 TRP206 TYR210 D: ASN262 ASP263 MET264 PRO265 ILE266 THR267 ASN268 ASP269 LYS271 LYS272 ASN276 ASP310 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
